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- W2380102831 abstract "Objective This study investigated the role of 17beta-estradiol (E2) in intestinal ischemia-reperfusion (I/R) injury in pubertal rats and its possible effect on iNOS expression. Methods The rats were randomly divided into 4 groups (each group,n=15). Rats of pubertal age were ovariectomized and injected subcutaneously with vehicle (control group) or E2 (100 or 500 mug/kg/every other day,E2 or 5E2 group) for 4 weeks. Other rats of the same age underwent sham ovariectomy as sham-op group. The rats in each group were subjected to 30 minutes occlusion of superior mesenteric artery followed by 1 hour (n=5),6 hours (n=5),or 24 hours (n=5) reperfusion. The blood of rats was obtained for the determination of E2 concentration. Intestine specimens then were harvested for the determination of histopathologic score,mRNA expression of inducible nitric oxide synthase (iNOS),and iNOS activity. Results In control,sham-op,E2,and 5E2 groups,the histopathologic scores were 3.31±0.12,3.00±0.09,2.57±0.12,and 2.98±0.08,respectively. The expression levels of iNOS mRNA were 3.85±0.42,4.86±0.76,5.17±0.34,and 4.25±0.41log copies,respectively. Lower histopathologic score but higher iNOS mRNA expression were found in E2 group than in the other groups (P 0.01). The level of iNOS activity paralleled the expression of iNOS mRNA,A negative lenear correlation was found between the log value of E2 concentration and histopathologic score (P 0.05). A positive linear correlation was found between the log value of E2 concentration and iNOS mRNA expression (P 0.01). Conclusions Estrogen may exert a protective effect on intestinal I/R injury in pubertal rats,probably by enhancing iNOS expression." @default.
- W2380102831 created "2016-06-24" @default.
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- W2380102831 date "2008-01-01" @default.
- W2380102831 modified "2023-09-23" @default.
- W2380102831 title "Protective effect of estrogen on intestinal ischemia-reperfusion injury in pubertal rats and its possible effect on iNOS expression" @default.
- W2380102831 hasPublicationYear "2008" @default.
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