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- W2380107898 abstract "Objective:To study mechanisms of early treatment of cerebral ischemia-reperfusion(I/R) by acupuncture in resisting inflammation injury in rats.Method:Cerebral I/R Model was established by occlusion of the middle cerebral artery for 1h and then removal of the occlusion at 3h,12h,24h and 48h respectively.The expression of ICAM-1 mRNA and protein was displayed by using imunohistochemical ABC and in situ hybridization techniques in ischemic cerebral cortex and corpus striatum in rats.The change of leukocytes myeloperoxidase in cerebral ischemic region,was assayed with a spectrometer system.Result:The mRNA expression of ICAM-1 was detected at capillary endothelia cells in ischemic cerebral cortex at 1h ischemia-3h reperfusion and peaked at 1h ischemia-12h reperfusion,The protein expression of ICAM-1 was detected at capillary walls in post ichemia cerebral cortex at 1h ischemia-3h reperfusion and peaked at 1h ischemia-24h reperfusion and increased continually during 48h reperfusion.Both mRNA and protein expression of ICAM-1 in ischemic cerebral cortex were down-regulated considerably by galvano-acupuncture treatment(P0.01).Conclusion:The protective effect of acupuncture on cerebral neurons under acute infarction is possible through it downregulative action on the mRNA and protein expression of ICAM-1,which caused neutrophil infiltration that induced by adhesive molecules between endothelium cell and neutrophil." @default.
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- W2380107898 date "2007-01-01" @default.
- W2380107898 modified "2023-09-25" @default.
- W2380107898 title "Effects of galvano-acupuncture on neutrophil infiltration and the expression of ICAM-1 mRNA and protein of cerebral ischemic region in rats" @default.
- W2380107898 hasPublicationYear "2007" @default.
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