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- W2380121911 abstract "Aim:To investigate the proliferation,migration and differentiation of neural stem cells(NSCs) mobilized by recombinant human granulocyte colony-stimulating factor(rhG-CSF)in cerebral palsy from fetal hypoxia-ischemia rats.Methods:SD rats aged 45 d in good health were randomly divided into 3 groups:the sham operation group,cerebral palsy from fetal hypoxia-ischemia model group and rhG-CSF treatment group.12 h after the complete of model,the treatment group received rhG-CSF at 40 μg/(kg·d),the other two groups received normal saline.BrdU was intraperitoneally injected at 10 mg/(kg·d ) for 5 consecutive days(5 days group) and 21 consecutive days(21 days group).BrdU+NeuN,BrdU+GFAP,BrdU+PSA-NCAM positive cells in cerebral cortex and hippocampus were detected by double immuno-fluorescence.Results:Compared with the sham operation group,BrdU,BrdU+NeuN,BrdU+PSA-NCAM,and BrdU+GFAP positive cells in cerebral cortex and hippocampus were more in model group(P0.05).Compared with the model group,they were more in the treatment group(P0.05).In treatment group,BrdU+NeuN positive cells in hippocampus of 5 days group were less than that of 21 days group (t=2.279,P=0.038),while BrdU+GFAP positive cells were more(t=7.220,P0.001).Conclusion:rhG-CSF can promote the proliferation,migration and differentiation of endogenous NSCs,and increase of new neurons and glial cells in fetal hypoxia-ischemia rats." @default.
- W2380121911 created "2016-06-24" @default.
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- W2380121911 date "2010-01-01" @default.
- W2380121911 modified "2023-09-26" @default.
- W2380121911 title "Effect of rhG-CSF on proliferation,migration and differentiation of neural stem cells in cerebral palsy from fetal hypoxia-ischemia rats" @default.
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