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- W2380125192 abstract "OBJECTIVE:To study the effect of Survivin antisense oligodeoxg nucleotide (ASON) on drug resistance and its mechanism in K562/A02 cells. METHODS:Survivin ASODN was transfected to K562/A02 cells by liposomal reagent, IC_ 50 (s) of adriamycin (ADM) and ADM+ASODN were detected by MTT assay. Changes in expression of Survivin mRNA and Survivin protein, activity of caspase-3 and apoptosis were detected by RT-PCR, Western blot, the fluorometer and flowcytometer. RESULTS:IC_ 50 (s) of ADM and ASODN+ADM were 45.56 mg/L and 19.01 mg/L, respectively. Expression of survivin mRNA and protein decreased by 36.2% and 71.5%, respectively. Activity of Caspase-3 increased by 67.5% and apoptosis was significantly higher than that in the controls [(14.5±5.6)% vs (2.4±1.0)%, P0.05]. CONCLUSION: Survivin ASODN is able to reverse the drug resistance via inhibition of survivin expression, activation of Caspase-3 and inducement of apoptosis." @default.
- W2380125192 created "2016-06-24" @default.
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- W2380125192 date "2006-01-01" @default.
- W2380125192 modified "2023-09-23" @default.
- W2380125192 title "Study on reversal of drug resistance in K562/A02 cells by antisense oligodeoxynucleotide targeting survivin" @default.
- W2380125192 hasPublicationYear "2006" @default.
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