Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380128972> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2380128972 abstract "Objective To investigate the effect of dexamethasone on cytokines secreted by monocyte and monocyte apoptosis in bronchial asthma (BA). Methods Monocytes from 30 asthma patients and 15 normal (NL) donors were isolated by density centrifugation with Ficoll-Hypaque and adherent incubation, then were cultured with or without dexamethasone. After a 24-hour incubation, granulocyte macrophage colony-stimulating factor (GM-CSF),tumor necrosis factor-α (TNF-α) were measured in the culture supernatants by an enzyme-linked immunosorbent assay (ELISA) . Apoptotic cells were analysed by DNA electrophoresis and flow cytometry. Results The basal production of GM-CSF and TNF-α was higher in the monocyte of BA individuals (P0.01), cultures of BA monocytes exhibited a significantly lower apoptosis rate than the NL monocytes (P0.01). After stimulated by dexamethasone,the production of cytokines decreased; there was no significant difference between the two groups, apoptosis of BA monocytes enhanced (P0.05). Conclusion Dexamethasone may have an effect for inhibiting the production of pro-inflammatory cytokines GM-CSF and TNF-α of monocytes, and enhancing the monocyte apoptosis in BA.This may become one of its antiasthmatic mechanisms." @default.
- W2380128972 created "2016-06-24" @default.
- W2380128972 creator A5026567141 @default.
- W2380128972 date "2004-01-01" @default.
- W2380128972 modified "2023-09-25" @default.
- W2380128972 title "Effect of dexamethasone on monocyte in bronchial asthma" @default.
- W2380128972 hasPublicationYear "2004" @default.
- W2380128972 type Work @default.
- W2380128972 sameAs 2380128972 @default.
- W2380128972 citedByCount "0" @default.
- W2380128972 crossrefType "journal-article" @default.
- W2380128972 hasAuthorship W2380128972A5026567141 @default.
- W2380128972 hasConcept C126322002 @default.
- W2380128972 hasConcept C134018914 @default.
- W2380128972 hasConcept C137061746 @default.
- W2380128972 hasConcept C153911025 @default.
- W2380128972 hasConcept C17991360 @default.
- W2380128972 hasConcept C185592680 @default.
- W2380128972 hasConcept C190283241 @default.
- W2380128972 hasConcept C202751555 @default.
- W2380128972 hasConcept C203014093 @default.
- W2380128972 hasConcept C25642318 @default.
- W2380128972 hasConcept C2777478134 @default.
- W2380128972 hasConcept C2778690821 @default.
- W2380128972 hasConcept C2780401358 @default.
- W2380128972 hasConcept C2781184567 @default.
- W2380128972 hasConcept C5362183 @default.
- W2380128972 hasConcept C553184892 @default.
- W2380128972 hasConcept C55493867 @default.
- W2380128972 hasConcept C71924100 @default.
- W2380128972 hasConcept C86803240 @default.
- W2380128972 hasConceptScore W2380128972C126322002 @default.
- W2380128972 hasConceptScore W2380128972C134018914 @default.
- W2380128972 hasConceptScore W2380128972C137061746 @default.
- W2380128972 hasConceptScore W2380128972C153911025 @default.
- W2380128972 hasConceptScore W2380128972C17991360 @default.
- W2380128972 hasConceptScore W2380128972C185592680 @default.
- W2380128972 hasConceptScore W2380128972C190283241 @default.
- W2380128972 hasConceptScore W2380128972C202751555 @default.
- W2380128972 hasConceptScore W2380128972C203014093 @default.
- W2380128972 hasConceptScore W2380128972C25642318 @default.
- W2380128972 hasConceptScore W2380128972C2777478134 @default.
- W2380128972 hasConceptScore W2380128972C2778690821 @default.
- W2380128972 hasConceptScore W2380128972C2780401358 @default.
- W2380128972 hasConceptScore W2380128972C2781184567 @default.
- W2380128972 hasConceptScore W2380128972C5362183 @default.
- W2380128972 hasConceptScore W2380128972C553184892 @default.
- W2380128972 hasConceptScore W2380128972C55493867 @default.
- W2380128972 hasConceptScore W2380128972C71924100 @default.
- W2380128972 hasConceptScore W2380128972C86803240 @default.
- W2380128972 hasLocation W23801289721 @default.
- W2380128972 hasOpenAccess W2380128972 @default.
- W2380128972 hasPrimaryLocation W23801289721 @default.
- W2380128972 hasRelatedWork W1562555601 @default.
- W2380128972 hasRelatedWork W1896382398 @default.
- W2380128972 hasRelatedWork W1974440224 @default.
- W2380128972 hasRelatedWork W1978344504 @default.
- W2380128972 hasRelatedWork W2006649589 @default.
- W2380128972 hasRelatedWork W2026644950 @default.
- W2380128972 hasRelatedWork W2045943275 @default.
- W2380128972 hasRelatedWork W2046122625 @default.
- W2380128972 hasRelatedWork W2050877178 @default.
- W2380128972 hasRelatedWork W2072390122 @default.
- W2380128972 hasRelatedWork W2095362351 @default.
- W2380128972 hasRelatedWork W2112234898 @default.
- W2380128972 hasRelatedWork W2117596960 @default.
- W2380128972 hasRelatedWork W2319389620 @default.
- W2380128972 hasRelatedWork W2343271354 @default.
- W2380128972 hasRelatedWork W2404652787 @default.
- W2380128972 hasRelatedWork W2429360031 @default.
- W2380128972 hasRelatedWork W2436257624 @default.
- W2380128972 hasRelatedWork W2978345802 @default.
- W2380128972 hasRelatedWork W2470968453 @default.
- W2380128972 isParatext "false" @default.
- W2380128972 isRetracted "false" @default.
- W2380128972 magId "2380128972" @default.
- W2380128972 workType "article" @default.