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- W2380129462 abstract "In 7 anaesthetized open-chest dogs,an intravenous injection of changrolin7 mg/kg brought forth a marked lowering of blood pressure and the work doneby left ventricle.The decreasing of coronary blood flow and aortic blood flowwere not significant,while the coronary vascular resistance tended to decline.During the period of lowering of the work done by left ventricle,the myocardialutilization of oxygen,lactic acid and pyruvic acid were not obviously affected.Two-stage left anterior coronary ligation was performed in 6 anaesthetizeddogs.After 24 hours,severe ventricular arrhythmias were recorded under consciousstate.An intravenous bolus of changrolin 5 mg/kg produced a remarkable anti-arrhythmic effect lasting about half an hour.The P-R interval,QRS complexand Q-T interval of sinus rhythm were not much altered.Since changrolin is very effective in controlling the ventricular arrhythmiaafter acute myocardial infarction in dogs,it deserves clinical trials." @default.
- W2380129462 created "2016-06-24" @default.
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- W2380129462 date "1979-01-01" @default.
- W2380129462 modified "2023-09-23" @default.
- W2380129462 title "EFFECTS OF CHANGROLIN ON CORONARY CIRCULATION AND THE POST-INFARCTION VENTRICULAR ARRHYTHMIA IN DOGS" @default.
- W2380129462 hasPublicationYear "1979" @default.
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