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- W2380147123 abstract "Aim To study the correlation between neuroprotection effect of ginsenoside Rg1 and the activation of nuclear factor kappa B (NF-κB) in neuronal cells induced by β-amyloid peptide 25-35 (Aβ25-35).Methods Rat astrocyte and hippocampal neuron cell models of Alzheimers disease (AD) were induced by Aβ25-35, respectively. The optimal concentration and duration of Aβ25-35 for cell models of AD and the optimal concentration and duration of Rg1 for pretreatment were determined according to cellular morphology and MTT colorimetric analysis. The activity of NF-κB in two kinds of cells was analyzed by laser scanning confocal microscope (LSCM) with double marked by FITC/PI. Results Aβ25-35(40 μmol·L-1for 24 h) was selected as the stable effective concentration and time point to make cell models of AD in neurons and astrocytes. 40 μmol·L-1 of Aβ25-35 up-regulates the activity of NF-κB (P0.01) in astrocytes and down-regulates the activity of NF-κB in neurons(P0.01). 2 μmol·L-1 of Ginsenoside Rg1 protects neurons through switching on the activation of NF-κB (P0.01), and protects astrocytes through inhibiting the degree of activation NF-κB (P0.01).Conclusion Ginsenoside Rg1 protects neurons through down-regulating the activity of NF-κB in astrocytes and up-regulating the activity of NF-κB in neurons. These results give new evidence and mechanism that Ginsenoside Rg1 has therapeutic benefits in AD." @default.
- W2380147123 created "2016-06-24" @default.
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- W2380147123 date "2007-01-01" @default.
- W2380147123 modified "2023-09-23" @default.
- W2380147123 title "Effects of Ginsenoside Rg1 on the activation of NF-κB in neuronal cells induced by Aβ_(25-35)" @default.
- W2380147123 hasPublicationYear "2007" @default.
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