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- W2380159299 abstract "Objective To study the role of WYE-354,an ATP-competitive mammalian target of rapamycin(mTOR) kinase inhibitor,in anti-rejection of mice after skin allograft and its mechanism.Methods A skin allograft model was established with BALB/c mice as the donor and C57BL/6 mice as the recipient.The mice were divided into auto-graft group(control group) and allograft group(WYE-354 group).Mice in control group were given rapamycin and WYE-354 2 days after operation for 2 days and those in WYE-354 group received oral 0.2ml rapamycin(1mg/kg·d) and injection of WYE-354 at dose of 1mg/(kg·d),1.5mg/(kg·d) and 50mg/(kg·d),respectively.On days 3,7,11,and 21 after operation,4E-BP1 phosphorylation levels in spleen cells were measured by Western blot.On day 11 after operation,skin tissue sample was stained with HE.Results The survival time of mice in WYE-354 group was longer than that of mice in control group(P0.01).The survival time of mice in control group was longer than that of mice in medium and high dose WYE-354 groups(P0.01).The number of locally-infiltrated lymphocytes was less in low dose WYE-354 group than in control group.The 4E-BP1 phosphorylation level in spleen cells was down-regulated in control group and low,medium and high WYE-354 groups,especially in high dose WYE-354 group.Conclusion WYE-354 can inhibit the 4E-BP1 phosphorylation level related with the mTOR signal transduction pathway,block the cell cycle,reduce the infiltration of lymphocytes to skin grafts,and prolong the survival time of mice after skin graft." @default.
- W2380159299 created "2016-06-24" @default.
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- W2380159299 date "2012-01-01" @default.
- W2380159299 modified "2023-09-28" @default.
- W2380159299 title "WYE-354 regulates signal transduction pathway of mammalian target of rapamycin in anti-rejection of mice after skin allograft" @default.
- W2380159299 hasPublicationYear "2012" @default.
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