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- W2380180835 abstract "To explore the mechanism of Cadmium Chloride on chondriosome damage of chicken neurons,neurons cultured in vitro were chose as the research object.Neurons were cultivated in the DMEM for 24 h with the final concentration of CdCl2 was 0,5,10,15 μmol/L,respectively.The inhibition ratio of neurons was evaluated with MTT colorimetric assay.The mitochondrial membrane potential(ΔΨm) was assessed by flow cytometry,and the calcium ion concentration within neurons(i) was detected using the Fura-2/AM as the probe.The results showed that the cells inhibition ratio was increased,i was increased,ΔΨm tended to degrade and the chondriosome cristae appeared ambiguity,fragmentation,disappearance,mitochondrial matrix was intumesced and vacuolized.The results indicated that CdCl2 could cause the impairment of the mitochondrial membrane of neurons by increasing the i,inducing the PT pore to open,degrading ΔΨm." @default.
- W2380180835 created "2016-06-24" @default.
- W2380180835 creator A5055114063 @default.
- W2380180835 date "2008-01-01" @default.
- W2380180835 modified "2023-09-26" @default.
- W2380180835 title "The Effect of Calcium Homeostasis Disequilibrium on the Impairment of the Neuron Mitochondria in the Chicken Brain Induced by Cadmium" @default.
- W2380180835 hasPublicationYear "2008" @default.
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