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- W2380185536 abstract "[Objective] To evaluate the cardioprotective effects offered by adenosine triphosphate(ATP),and discuss it's protective mechanism.[Methods] In anesthetized open-chest rabbits,the left anterior descending artery(LAD) was occluded for 40 mins and reperfused for 3 hours.In control group(n=16),there was no intervention.In preconditioning group(n=16),the LAD was occluded for 5 mins and reperfused for 10 mins,and repeated this process for three times before the prolonged occluded.In postconditioning group(n=16),at the start of reperfusion,three cycles of 30-s reperfusion and 30-s LAD reocclusion preceded the 3 hours of reperfusion.In ATP group(n=16),at the start of reperfusion,ATP(4 mg/kg) was injected within 30 mins.[Results] The expression of NF-kB and apoptosis rate in the control group was significantly higher than that of other groups(P0.01).Infarct size was significantly smaller in the preconditioning group,postconditioning group and ATP group(P0.01),compared with control group.[Conclusions] ATP has a good cardioprotective effects for cardiomyocytes with ischemic reperfusion,which partly due to the redusing of apoptosis." @default.
- W2380185536 created "2016-06-24" @default.
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- W2380185536 date "2007-01-01" @default.
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- W2380185536 title "Effects of ATP postconditioning on apoptosis and NF-κB expression of cardiomyocytes with ischemic reperfusion" @default.
- W2380185536 hasPublicationYear "2007" @default.
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