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- W2380191569 abstract "Objective:To investigate the gene expression levels of proinflammation cytokines and tyrosine hydroxylase of schizophrenic, and explore the relation of gene expression levels and the score of PANSS scale.Methods:The clinical symptom of 39 schizophrenic patients were evaluated by PANSS scale, and the gene expression levels of IL-1β, TNF-α and TH in the peripheral blood mononuclear cell were measured with RT-PCR and semi-quantification technique. 25 sibling controls and 30 normal controls also received gene expression measurements. Results:The gene expression levels of IL-1β was 1.52±1.01 in schizophrenic, 1.18±0.99 in sibling controls and 0.55±0.33 in normal controls; the gene expression levels of TNF-α was 1.52±1.09 in schizophrenic, 1.01±0.87 in sibling controls and 0.61±0.32 in normal controls; the gene expression levels of TH was 0.74±0.38 in schizophrenic, 0.70±0.29 in sibling controls and 0.28±0.20 in normal controls. No significant difference in each gene expression level was found between schizophrenic and siblings (P0.05), but each gene expression level was higher in schizophrenic or siblings than in normal controls (P0.01 or 0.05). The correlation between the scores of general symptom scale of PANSS and the gene expression levels of IL-1β(r=0.420), TNF-α(r=0.430) was significant(P0.01).Conclusions:Proinflammation cytokines and catecholamines have over-expression in the peripheral blood mononuclear cell of schizophrenics. Hereditary factor maybe play a very important role in the regulation of gene expression levels. The proinflammation cytokines may have a relationship with the general symptom of schizophrenia." @default.
- W2380191569 created "2016-06-24" @default.
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- W2380191569 date "2006-01-01" @default.
- W2380191569 modified "2023-09-25" @default.
- W2380191569 title "The Relationship of Gene Expression Levels of Proinflammation Cytokines, Tyrosine Hydroxylase of Schizophrenic and PANSS Score" @default.
- W2380191569 hasPublicationYear "2006" @default.
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