FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380201691> ?p ?o ?g. }

• W2380201691 endingPage "58" @default.
• W2380201691 startingPage "a46" @default.
• W2380201691 abstract "The binding of an immunoglobulin lambda light chain (IgLC) to synthetic and biological membranes was monitored in real-time using a recently developed, time-resolved fluorescence technique. Lambda IgLC purified from the urine of patients with multiple myeloma, were used in studies of protein-membrane interactions. The association of the lambda IgLC dimer with B-lymphocytes was shown to be stabilised predominantly by non-polar interactions. Furthermore, it was found that following binding to synthetic phospholipid membranes, a reorientation of the light chain occurred which resulted in a change in the distribution of charged residues at the lipid-water interface. The rate constants associated with the binding event were calculated, and appear to comprise both temperature insensitive and sensitive components. The calculated activation energies of the binding and reorientation events were found to be 13.53 KJmol(-1) and 87.89 KJmol(-1), respectively. The large activation energy associated with the reorientation phase suggests the movement of large protein domains, possibly involving a whole immunoglobulin domain. The binding and reorganisation of the IgLC upon the phospholipid membrane may confer novel biological functions to the bound protein and potentially contribute to such phenomenon as myeloma-associated immuno-suppression." @default.
• W2380201691 created "2016-06-24" @default.
• W2380201691 creator A5007902682 @default.
• W2380201691 date "1996-01-01" @default.
• W2380201691 modified "2023-10-14" @default.
• W2380201691 title "A study of the interactions of an immunoglobulin light chain with artificial and B-lymphocyte membranes" @default.
• W2380201691 cites W130559879 @default.
• W2380201691 cites W1485309471 @default.
• W2380201691 cites W1492931340 @default.
• W2380201691 cites W1569572827 @default.
• W2380201691 cites W1572253423 @default.
• W2380201691 cites W1604560619 @default.
• W2380201691 cites W1792170917 @default.
• W2380201691 cites W1976360886 @default.
• W2380201691 cites W1985409973 @default.
• W2380201691 cites W1994292399 @default.
• W2380201691 cites W2001193614 @default.
• W2380201691 cites W2021949777 @default.
• W2380201691 cites W2027920027 @default.
• W2380201691 cites W2031078693 @default.
• W2380201691 cites W2032518322 @default.
• W2380201691 cites W2032938931 @default.
• W2380201691 cites W2036549249 @default.
• W2380201691 cites W2044135934 @default.
• W2380201691 cites W2059815360 @default.
• W2380201691 cites W2073005665 @default.
• W2380201691 cites W2082046787 @default.
• W2380201691 cites W2083150508 @default.
• W2380201691 cites W2086543293 @default.
• W2380201691 cites W2093229658 @default.
• W2380201691 cites W2093504415 @default.
• W2380201691 cites W2104864926 @default.
• W2380201691 cites W2109134103 @default.
• W2380201691 cites W2132050884 @default.
• W2380201691 cites W2134800117 @default.
• W2380201691 cites W2136702130 @default.
• W2380201691 cites W2168220893 @default.
• W2380201691 cites W2172083794 @default.
• W2380201691 cites W2258778632 @default.
• W2380201691 cites W2270610762 @default.
• W2380201691 cites W2320370801 @default.
• W2380201691 cites W2338690157 @default.
• W2380201691 cites W238314845 @default.
• W2380201691 cites W2402872663 @default.
• W2380201691 cites W2405833111 @default.
• W2380201691 cites W2410421521 @default.
• W2380201691 cites W51893898 @default.
• W2380201691 cites W2411484871 @default.
• W2380201691 doi "https://doi.org/10.2741/a105" @default.
• W2380201691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9159194" @default.
• W2380201691 hasPublicationYear "1996" @default.
• W2380201691 type Work @default.
• W2380201691 sameAs 2380201691 @default.
• W2380201691 citedByCount "17" @default.
• W2380201691 countsByYear W23802016912013 @default.
• W2380201691 countsByYear W23802016912014 @default.
• W2380201691 countsByYear W23802016912018 @default.
• W2380201691 countsByYear W23802016912019 @default.
• W2380201691 crossrefType "journal-article" @default.
• W2380201691 hasAuthorship W2380201691A5007902682 @default.
• W2380201691 hasConcept C120665830 @default.
• W2380201691 hasConcept C121332964 @default.
• W2380201691 hasConcept C12554922 @default.
• W2380201691 hasConcept C159654299 @default.
• W2380201691 hasConcept C185592680 @default.
• W2380201691 hasConcept C188758523 @default.
• W2380201691 hasConcept C203014093 @default.
• W2380201691 hasConcept C2778113609 @default.
• W2380201691 hasConcept C2778918659 @default.
• W2380201691 hasConcept C36394416 @default.
• W2380201691 hasConcept C41625074 @default.
• W2380201691 hasConcept C55493867 @default.
• W2380201691 hasConcept C86803240 @default.
• W2380201691 hasConceptScore W2380201691C120665830 @default.
• W2380201691 hasConceptScore W2380201691C121332964 @default.
• W2380201691 hasConceptScore W2380201691C12554922 @default.
• W2380201691 hasConceptScore W2380201691C159654299 @default.
• W2380201691 hasConceptScore W2380201691C185592680 @default.
• W2380201691 hasConceptScore W2380201691C188758523 @default.
• W2380201691 hasConceptScore W2380201691C203014093 @default.
• W2380201691 hasConceptScore W2380201691C2778113609 @default.
• W2380201691 hasConceptScore W2380201691C2778918659 @default.
• W2380201691 hasConceptScore W2380201691C36394416 @default.
• W2380201691 hasConceptScore W2380201691C41625074 @default.
• W2380201691 hasConceptScore W2380201691C55493867 @default.
• W2380201691 hasConceptScore W2380201691C86803240 @default.
• W2380201691 hasIssue "1" @default.
• W2380201691 hasLocation W23802016911 @default.
• W2380201691 hasLocation W23802016912 @default.
• W2380201691 hasOpenAccess W2380201691 @default.
• W2380201691 hasPrimaryLocation W23802016911 @default.
• W2380201691 hasRelatedWork W117434477 @default.
• W2380201691 hasRelatedWork W1503190569 @default.
• W2380201691 hasRelatedWork W1536984596 @default.
• W2380201691 hasRelatedWork W2000120282 @default.
• W2380201691 hasRelatedWork W2048954453 @default.
• W2380201691 hasRelatedWork W2091394389 @default.
• W2380201691 hasRelatedWork W2143243732 @default.

• next