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- W2380201996 abstract "Objective To detect the relation between 5-HT2A receptor gene polymorphism and Alzheimerdisease(AD) in Chinese. Methods The gene polymorpism of 5-HT2A recepto gene and ApoE were genotyped in82 AD cases, 97 controls with PCR methods and RFLP typing. Then the association between 5-HT2A receptor genepolymorphism and AD was analyzed. Results There was no association between AD and any allele or genotype of5-HT2A meceptor gene polymorphism. But when the subjects were split into ApoE e4 plsitive and ApoE e4 negativegroups, there was a significantly positive association between non-ApoE e4 AD and A1/A2 genotype (OR = 2. 72,95% CI: 2. 10 ~ 3. 52, P＜0. 05), or a negative association between non-ApoE e4 AD and A1/A1 genotype(OR = 0.36, 95% CI: 0.32~0.40, P＜0.05). Conclusions The 5-HT2A receptor gene polymorpsm may beassociated with non-ApoE e4 AD in Chinese Han population." @default.
- W2380201996 created "2016-06-24" @default.
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- W2380201996 date "1999-01-01" @default.
- W2380201996 modified "2023-09-22" @default.
- W2380201996 title "The relation between 5-HT_(2A) receptor gene polymorphism and Alzheimer's disease in Chinese" @default.
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