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- W2380201999 abstract "Objective To study the effects of moderate exercise and thyroid hormone adding on the liver H_2O_2 content and anti-oxidative capability in rats.Methods Wistar rats were randomly divided into eight groups,control(C),mild hyperthyroidism (T_1),severe hyperthyroidism(T2) and hypothyroidism(J),furthermore,each group were divided into two groups,such as exercise and no exercise.The model of mild hyperthyroidism(T_1),severe hyperthyroidism(T_2)and hypothyroidism(J) rats were established by giving 100μg/d levothyroxine sodium(L-T_4),200μg/d L-T_4 and 10 mg/d methimazole respectively.After 14 d of treatment, the rats were sacrificed and liver H_2O_2 content,GPx activity,SOD activity and MDA content were measured.Results All of the H_2O_2 content,GPx activity,SOD activity and MDA content were higher in hyperthyroidism group,and which were lower in hypothyroidism group.Furthermore,given by levothyroxine or methimazole,all indexes were higher in exercise group than those of no exercise group,however,there was no difference in the MDA content between exercise group and control group. Conclusion Both exercise and hyperthyroidism may induce the increasing of H_2O_2 content and the anti-oxidative capability in the liver of rats,and the synergistic effect has been observed.Exercise plus hyperthyroidism,exercise plus hypothyroidism and hyperthyroidism may induce oxidative damage." @default.
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- W2380201999 date "2012-01-01" @default.
- W2380201999 modified "2023-09-25" @default.
- W2380201999 title "Effects of Moderate Exercise and Thyroid Hormone Adding on Oxidative Stress of Liver in Rats" @default.
- W2380201999 hasPublicationYear "2012" @default.
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