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- W2380212154 abstract "Objective To establish an animal model of pituitary adenoma to carry out the fundamental study on pituitary adenoma.Methods A newly established malignant pituitary somatoroph cell line (mGH 3) was cultured in vitro.mGH 3 cells were implanted stereostaxically into the lateral cerebral ventricle in Wistar Furth rats.The growth of the transplanted tumors was pathologically examined and circulating rGH levels measured by using RIA methods.Results The mGH 3 cell line demonstrated the features of secretion of rGH.The tumor bearing rats showed various acromegaloid symptoms such as soft tissue swelling,hypertrophy of extremities and increased hair growth.The survival of mGH 3 tumor bearing rats was ( 44.2± 5.6) days.Histological examination revealed that the tumor was invasive to the normal brain and markedly anaplastic cells and neovascularization were identified.Circulating GH levels were gradually increased at 3 weeks after mGH 3 transplantation.Conclusion The established malignant pituitary tumor(mGH 3) possesses a malignant phenotype that is invasive and hypervascular and also demonstrates features of GH secretion." @default.
- W2380212154 created "2016-06-24" @default.
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- W2380212154 date "2000-01-01" @default.
- W2380212154 modified "2023-09-26" @default.
- W2380212154 title "Establishment of transplanted malignant pituitary adenoma model in rats and its biological characters" @default.
- W2380212154 hasPublicationYear "2000" @default.
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