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- W2380226723 abstract "OBJECTIVE To set up model of otitis media with effusion in SD rat.METHODS Thirty-four SD rats were used with one side of ear as model group and the other side as contrast group.The pharyngeal orifice of eustachian tube of rats were cauterized with trichloroacetic acid by soft palatine approach to set up secretory otitis media model.The tympanic membrane was studied by otoscopy,conbined with the detection of acoustic immittance and ABR.Besides,the changes of mucus of eustachian tube and tympanic cavity were observed by HE staining.RESULTS Twenty-eight of thirty-four ears of SD rats formed serous effusion with disappearance of light cone.Acoustic immittance showed the changes of peak of pressure from second to sixth day postoperatively.Mucosal edema was found under otoscopy and lots of inflammatory cells were found under light microscope.CONCLUSION It is a feasible way to set up model of otitis media with effusion by cauterizing the pharyngeal orifice of eustachian tube of rats with trichloroacetic." @default.
- W2380226723 created "2016-06-24" @default.
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- W2380226723 date "2009-01-01" @default.
- W2380226723 modified "2023-09-27" @default.
- W2380226723 title "Model of otitis media with effusion in SD rat" @default.
- W2380226723 hasPublicationYear "2009" @default.
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