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- W2380230392 abstract "Objective To investigate the protective effect on liver grafts by extra-corporeal liver perfusion with heme oxygenase-1(HO-1) inducer cobalt protoporphyrin(CoPP) during hypothermic storage on rat orthotopic liver transplantation model.Methods Liver grafts were taken from Wistar rats and transplanted to SD rats.Extra-corporeal liver perfusions of liver grafts were performed during hypothermic storage with different solution before OLT.The rats were divided into control group,CoPP group,nodosin(which is effective component in Isodon Serra) group and ZnPP(which is HO-1 inhibitor) group with twelve pairs of rats in each group.The rat grafts were perfused with lactated Ringer's solution,125 μg/ml CoPP,200 μg/ml nodosin and 500 μg/ml ZnPP respectively before OLT.On day 1,Day 3,Day 7 and Day 21 after OLT,three recipient rats in each group were killed and liver specimens were collected.HE staining pathological examination and Suzuki score were performed.Results On day 1,Day 3 and Day 7 after OLT,the pathological damage of liver in CoPP group and nodosin group were slighter compared with the control group and ZnPP group,but the Suzuki score of each group showed no statistically significance(P0.05).On day 21 after OLT,the pathological damage of liver in CoPP group and nodosin group were slighter than that in control group,and there was statistically significant difference in the Suzuki score between every two groups(P0.05 and P0.01,respectively).The pathological damage of liver in ZnPP group was severe,and there was statistically significant difference in the Suzuki score between nodosin group and ZnPP group(P0.01).Conclusions Extra-corporeal liver perfusion with HO-1 inducer during hypothermic storage can reduce the pathological damage of liver after OLT in rats,and the protective effect on liver grafts was better in the later period after OLT." @default.
- W2380230392 created "2016-06-24" @default.
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- W2380230392 date "2010-01-01" @default.
- W2380230392 modified "2023-09-23" @default.
- W2380230392 title "Protection of liver grafts with HO-1 inducer by extra-corporeal liver perfusion in rats" @default.
- W2380230392 hasPublicationYear "2010" @default.
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