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- W2380233463 abstract "Objective Exploring the effects of advanced glycosylation end product (AGE) on human osteoblastic cell proliferation and secreting cytokines,for revealing the role of AGE in the pathogenesis of senile osteoporosis. Methods Cells from fetal calvaria were incubated for different periods of time after exposure to different doses of AGE|BSA or BSA so as to assess time|dependent and dose|dependent pattern of AGE|BSA effect on human osteoblastic cell proliferation and secreting cytokine. Results After 48 h incubation,100 μg/ml AGE|BSA significantly promoted the secretion of IL|6 from human osteoblastic cells.There was no significant difference in production of IL|6 and TNF|α between AGE|BSA and BSA at doses ranging from 200 μg/ml to 1000 μg/ml AGE|BSA.After 24 h incubation,100 μg/ml AGE|BSA significantly inhibited human osteoblastic cell proliferation.After 48 h and 72 h incubation,100-1000 μg/ml AGE|BSA significantly induced a dose|dependent increase in human osteoblastic cell proliferation. Conclusion High concentration of AGE induces strongly stimulative effect on human osteoblastic cell proliferation,suggesting that human osteoblastic cells have an increased tolerance to high level AGE,which might be associated with the life span of different species.There is no significant differencent in effects on IL|6 and TNF α production between AGE|BSA and BSA after exposure of the cells to high level AGE,suggesting that osteoblast|mediated bone resorption induced by increased AGE is not obviously increased.This fact corresponds with decreased bone turnover in old people,who have higher AGE in their body.;" @default.
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- W2380233463 date "2001-01-01" @default.
- W2380233463 modified "2023-09-27" @default.
- W2380233463 title "Effects of advanced glycosylation end product on human osteoblastic cell proliferation and secreting cytokine" @default.
- W2380233463 hasPublicationYear "2001" @default.
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