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- W2380236564 abstract "Objective To investigate a more repeatable and stable method of nasopharyngeal carcinoma(NPC) apparent diffusion coefficient(ADC) values measurement through the comparion of two different methods. Method one: round region of interest area about 30mm2 was placed at the center of primary leision(Regional Measurement Method, R-method). Method two:the edge of the leision was outlined manually including the whole of tumor in the largest slice(Whole Measurement Method,W-method). Methods Conventional MRI scans and DW-MRI scans were continuously performed in 100 patients with NPC confirmed pathology. Two radiologists measured the ADC values with R-method and W-method independently. Pairedsamples t-test, Pearson correlation analysis and Bland-Altman analysis were adopted to evaluate the differences of tumor ADC values, the correlation coefficient and the consistency of the two methods of measurement respectively. Statistical significance was defined by a P value of 0.05.Tumor ADC values were measured with the two different methods and the coefficient of variations(CV) were calculated by five investigators at five different time points in order to evaluate the stability of the two methods of measurement. Results The ADC values were(0.79 ± 0.14)× 10-3mm2/s(W-method) and(0.76 ± 0.15)× 10-3mm2/s(R-method) by observer 1;and(0.82 ± 0.18)× 10-3mm2/s(W-method) and(0.78 ± 0.20)× 10-3mm2/s(R-method) by observer 2. The ADC values were lower used R-method than that with W-method(observer 1: t=-5.739,P0.001;observer 2: t=-5.221,P0.001). The correlation coefficient of R-method and W-method were 0.675 and 0.763 respectively. There were 5 values(5%) outside the consistent limitation by W-method and 6 values(6%) by R-method with Bland-Altman analysis. The CV of ADC values measured by W-method and R-method were 2% and 8% respectively. Conclusion There is good consistency and stability of ADC values measured by different methods of regional measurement and whole measurement. The ADC values measured by W-method is slightly superior than that by R-method in reproducibility and stability. Margin-outline whole-part measurement method(W-method)might be recommended to apply in the apparent diffusion coefficient values measurement of nasopharyngeal carcinoma through our study." @default.
- W2380236564 created "2016-06-24" @default.
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- W2380236564 date "2013-01-01" @default.
- W2380236564 modified "2023-09-24" @default.
- W2380236564 title "A Comparison Study of Two Different Apparent Diffusion Coefficient Values Measurement Methods Of Nasopharyngeal Carcinoma" @default.
- W2380236564 hasPublicationYear "2013" @default.
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