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- W2380241784 abstract "Objective This study was aimed to know the epidemiological characteristics and genotype of hepatitis E in Anhui Province by studying the molecular epidemiological characteristics of isolation clusters of the virus of acute scattered hepatitis E.The results would help to research the bacterin of hepatitis E.Methods The data of acute hepatitis E patients from the department of contagious diseases of four general hospitals in Anhui Province were collected from December 2006 to December 2007.On the basis of clinical diagnosis,the antigens and antibodies including HAV IgM,HBsAg,HBsAb,HBeAg,HBeAb,HBcAb,HCVAb,HEV IgM and IgG were tested by ELISA method.According to the diagnosis standards established by GB 17011-1997,once HEV IgM and IgG are positive combined with the symptoms and dysfunction of liver,then the patient should be diagnosed acute hepatitis E.The HEV RNA in the serum of 50 acute hepatitis E patients was examined by the method of RT-nPCR,and also cloning HEV was conducted to measure the sequence of HEV RNA and analyze the genotype of HEV by DNA STAR software for gene analysis.Results Among 50 serum tests,11 of them were PCR positive,and they were approved as HEV gene sequence.The positive rate of HEV RNA was 22%,2 cases were HEV typeⅠand 9 were HEV type Ⅳ in which 3 were type ⅣA and 6 were type ⅣD.The positive rate of HEV RNA was related to the time of test and the severity of liver dysfunction.Conclusions The symptoms are typical.The major gene type is type Ⅳ,and it has two subtypes." @default.
- W2380241784 created "2016-06-24" @default.
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- W2380241784 date "2009-01-01" @default.
- W2380241784 modified "2023-09-26" @default.
- W2380241784 title "Study on clinic characteristics and genotype of hepatitis E in Anhui Province" @default.
- W2380241784 hasPublicationYear "2009" @default.
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