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- W2380250075 abstract "Objective To explore the relationship between the expression of p16 and CDK4 and its significance.Method The immunohistochemistry was used to investigate the protein expression of p16 and CDK4 in a serial frozen sections of human osteosarcoma from 68 cases(36 were males and 32 were females).The correlations between the expression of p16 and CDK4 and the patients′ characteristics,including age,sex,clinical stage and histological types were studied.Results There was abundant p16 and CDK4 immunoreactivity in the nucleus and/or cytoplasm of the osteosarcoma cells with positive expression rates being 39.7% and 46.4% respectively.The positive expression rate and intensity of p16 in poorly differentiated osteosarcoma were significantly lower than those in well differentiated osteosarcoma(P0.01)and the expression of p16 was not correlated with sex,age and tissue type.The positive expression rate and intensity of CD44 in poorly differentiated osteosarcoma were significantly higher than those in well differentiated osteosarcoma(P0.01)and the expression of CDK4 also was not correlated with sex,age and tissme type.Expression of CDK4 was correlated negatively with expression of p16(r=-0.790,P0.01).Conclusion Expression of p16 and CDK4 is related to pathological stage of osteosarcoma." @default.
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- W2380250075 date "2006-01-01" @default.
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- W2380250075 title "Expressions of p16 and CDK4 in human osteosarcoma" @default.
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