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- W2380269541 abstract "Objective To assess the clone state of keloid by analyzing methylated state of human androgen (HUMARA) gene and detecting X-chromosome inactivation pattern. Methods Sixty-nine Thirty-four female patients were invoved in this study, 34 patients with keloids was as the kelois group, 35 patients with normal skin as the normal skin group. Samples were harvested from the both groups, and tissue DNA was extracted, and then digested with methylation sensitive restriction endonuclease HhaⅠ. HUMARA fragment was amplified with PCR method and PCR product was electrophoresed. Clonality was assessed by observing the electrophoresisbands. Results Heterozygotic rate of HUMARA was 85.29%. Polyclonal rates in keloid and normal skin group were 72.41%, 92.86%, respectively. Differences between them was statistically significant (P0.05). Conclusion The presence of polyclonal specimens indicated that keloids was not the result from clonal proliferation of neoplasm cells but the result from intrinsically normal cells that are responding to an abnormal extracellular signal. This result can guide future genetic and molecular studies to identify this proposed abnormal regulatory signal, which we expect to be an important regulator of normal and diseased scarring." @default.
- W2380269541 created "2016-06-24" @default.
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- W2380269541 date "2007-01-01" @default.
- W2380269541 modified "2023-09-25" @default.
- W2380269541 title "Analysis of clone state of keloid scars" @default.
- W2380269541 hasPublicationYear "2007" @default.
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