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- W2380283944 abstract "Objective:To study the expression and clinical significance of metastasis-related genes CD44V6 and human papilloma virus(HPV) in human laryngeal carcinoma.Methods: Detection of HPV and CD44V6 expression by using immunohistochemical S-P in 60 cases of laryngeal,30 cases of vocal cord polyps,5 cases of normal laryngeal tissue specimens.Results: Expression of CD44V6 and HPV in laryngeal carcinoma were 73.3%(44/60) and 56.7%(34/60) respectively,significantly higher than vocal polyps and normal laryngeal tissue(P0.01);The positive expression of HPV,CD44V6 in advanced(stage Ⅲ-Ⅳ),histological grade 2-3(low differentiation),and with neck lymph nodes transfer of laryngeal cancer were significantly higher than early(stageⅠ-Ⅱ),histological grade 1(high differentiation),and no neck lymph nodes transfer(P0.01).CD44V6 expression in the survivors of laryngeal cancer post-operative 3 or 5 years are significantly lower than the deceaseds,while the expression of HPV was not statistical different between survivors post-operative 3,5-year and the deceaseds.Expression of HPV was associated with CD44V6(P0.01).Conclusion: The occurrence,development and prognosis of laryngeal carcinoma are closely related to expression of HPV,CD44V6." @default.
- W2380283944 created "2016-06-24" @default.
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- W2380283944 date "2011-01-01" @default.
- W2380283944 modified "2023-09-26" @default.
- W2380283944 title "Expression and significance of CD44V6 and human papilloma virus (HPV) in laryngeal carcinoma" @default.
- W2380283944 hasPublicationYear "2011" @default.
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