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- W2380287110 abstract "ObjectiveTo study the biological characteristics of calcium phosphate nanoparticles and evaluate the promising in cancer gene therapy. Methods Calcium chloride modified nanoparticles prepared by means of chemistry. Analyse the combination of calcium phosphate nanoparticles and DNA, the protection to DNA as well by gelose gelatin electrophoresis. When the green fluorescence protein gene was regarded as report gene, gene vector of calcium phosphate nanoparticles transfected CNE- 2 cell in vitro and vivo. Combine the calcium phosphate nanopar- ticles and suicide gene yCDglyTK for Nasopharyngeal Carcinoma (NPC) therapy in vitro.ResultsCalcium phos- phate nanoparticles went into cell and could protect DNA after its combination with DNA by electro- microscopy. Regard calcium phosphate nanoparticles as vector of gene transfection, transduct green fluorescence protein gene in- to CNE- 2 cell, the green fluorescence protein high expression can be seen by fluorescence microsopy. The results of transfection in vivo showed that gene introduced by nanoparticles had a good expression in tumor tissue. The results of transducting suicide gene yCDglyTK by calcium phosphate nanoparticles for Nasopharyngeal Carcinoma (NPC) therapy in vitro indicated that large numbers of CNE- 2 cells were dead after the addition of 5- FC. ConclusionCalcium phosphate nanoparticles has great biological characteristics and it is one of promising vectors of gene trans- fection and gene therapy." @default.
- W2380287110 created "2016-06-24" @default.
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- W2380287110 date "2005-01-01" @default.
- W2380287110 modified "2023-09-25" @default.
- W2380287110 title "Calcium phosphate nanoparticles as a novel nonviral vector in cancer gene therapy" @default.
- W2380287110 hasPublicationYear "2005" @default.
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