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- W2380304856 abstract "Objective To study the effect of different doses of zinc on articular cartilage of Sprague-Dawley( SD) rat with osteoarthritis in early,middle phases and the expression of matrix metalloproteinase-13( MMP-13). Mehtods 64 SD rats were randomly diveded into four groups after had been an Modified Hulth modelling surgery on their knee joints,as follow: control group,low-dose zinc group,middle-dose zinc group and high-dose zinc group. The control group were treated with the normal saline at the same dose,and the cartilage sections were stained with hematoxylin-eosin( HE) and observed by light microscope,Mankin's score system was applied to analyze the degree of cartilage damage. The expression of MMP-13 in cartilage were detected using immunohistochemistry method. Positive expression was quantified by IOD score. Results At 4,8 weeks postoperatively,the degree of cartilage injury were more worse in the operation sides compared with the uninjured sides in control group,and there was a significant difference of Mankin scores between the two sides( P 0. 05). At 4 weeks postoperatively,there were no significant difference between the groups except the uninjured sides of control group. At 8 weeks postoperatively,Mankin scores was higher and the levels of MMP-13 expression was markedly lower in high-dose zinc group than that in control group( P 0. 05).Conclusions OA model was established successfully. Early interventiobn with high-dose zinc for 8 weeks could protect the cartilage in SD rats models of OA,and inhibited the expression of MMP-13 in cartilage tissue." @default.
- W2380304856 created "2016-06-24" @default.
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- W2380304856 date "2014-01-01" @default.
- W2380304856 modified "2023-09-23" @default.
- W2380304856 title "Effect of Zinc on Articular Cartilage of SD Rat with Osteoarthritis in Early,Middle Phases and the Expression of MMP-13" @default.
- W2380304856 hasPublicationYear "2014" @default.
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