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- W2380313785 abstract "Objective To explore the changes and correlation of serum prolactin,Interferon-γ(IFN-γ) and Interleukin-10(IL-10) levels in patients with uremia treated by maintenance hemodialysis(MHD). Methods 35 patients with uremia treated by MHD(the MHD group) and 20 healthy persons(the control group) were recruited for the study.Blood samples were collected after an overnight fast.The serum levels of IFN-r and IL-10 were measured by sandwich enzyme-linked immunosorbent assay(ELISA),and the levels of serum prolactin was determined by radioimmunoassay using RIA kits.BUN and creatinine(Scr) were also measured by the full-automatic biochemical instrument.The multiple correlations were analyzed among parameters including prolactin、IFN-γ、IL-10、BUN and Scr. Results The concentration of serum PRL in the MHD group were significantly higher than that in the control group(60.15±44.41μg/L vs 4.92±3.63μg/L,P0.01).So was the concentration of IFN-γ(35.30±18.23pg/ml vs 14.45±4.82 pg/m,P0.01l).There was no significant difference between serum IL-10 level in the MHD group and that in the control group(P0.05).The serum PRL level in the MHD group was positively correlated with the Scr level(r=0.40,P0.05)and so was tie IFN-γ level(r=0.45,P0.01).The serum PRL level in the MHD group was also positively correlated with the IFNγ level(r=0.52,P0.01),however,The serum PRL level in the MHD group was negatively correlated with the IL-10 level(r=-0.42,P0.05)and so was the IFN-γ level(r=-0.46,P0.01). Conclusion Our data suggest that the changes and interactions of serum prolactin、IFN-γ and IL-10 levels probably play a role in the immunoendocrine pathogenesis in patients with uremia treated by maintenance hemodialysis(MHD)." @default.
- W2380313785 created "2016-06-24" @default.
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- W2380313785 date "2007-01-01" @default.
- W2380313785 modified "2023-09-23" @default.
- W2380313785 title "Study on changes and correlation of serum prolactin,IFN-γ and IL-10 levels in patients with uremia treated by maintenance hemodialysis" @default.
- W2380313785 hasPublicationYear "2007" @default.
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