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- W2380329210 abstract "Objective To investigate the effects of IFN-α-1b on the expression of MMP-2 and TIMP-2 protein and the ratio of MMP-2/TIMP-2 in human hepatocellular carcinoma(HCC) cell line HepG2 cells and explore its molecular mechanism of inhibiting the growth and metastasis of HCC.Methods MMP-2,TIMP-2 concentration were measured in the supernate of HepG2 cells incubated in DMEM or exposed to differing dosages of IFN-α(30,300 or 3000 IU.ml-1) by ELISA.Results MMP-2 concentrations in the HepG2 cells incubated for 24 and 48 h exposure to IFN-α 3 000 IU.ml-1 were(1 725.3±300.7) and(2 899.8±343.2) pg.ml-1.There were significant differences compared with controls(P0.05),whereas no significant differences were found between TIMP-2 concentration of intervention groups and control groups.But there were significant differences between MMP-2/TIMP-2 ratio after incubation for 24 or 48 h.Conclusion IFN-α-1b treatment significantly decreases MMP-2/TIMP-2 ratio by inhibiting the expression of MMP-2 in HepG2 cells in a dose-dependent manner.The down-regulation of MMP-2 levels contributes,at least in part,to its activity of inhibiting the growth and metastasis of HCC." @default.
- W2380329210 created "2016-06-24" @default.
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- W2380329210 date "2011-01-01" @default.
- W2380329210 modified "2023-09-24" @default.
- W2380329210 title "Effects of IFN-α-1b on expression of MMP-2 and TIMP-2 protein in HepG2 cells" @default.
- W2380329210 hasPublicationYear "2011" @default.
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