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- W2380333719 abstract "Objective: To study the effects of different hormone replacement therapies with short and long term of use on serum lipids in postmenopausal women.Methods:Serum levels of 17 β-estradiol (E2),follicle stimulating hormone (FSH) and serum lipid levels in postmenopausal women were determined before and after short-term (3 months) use of estradiol valevate 1 mg/d (ERT) ( n =9) or estradiol valevate 1 mg/d plus medroxyprogesterone acetate (MPA) 2 mg/d (HRT) ( n =30). Same tests,as well as the levels of angiotensin II (Ang II) and nitric oxide (NO),were done in 11 postmenopausal women with the long term (9～29 years) use of multiple replacement therapies (mHRT).Results:(1) The concentration of E2 was increased to normal levels while FSH decreased in the postmenopausal women using ERT or HRT or mHRT. Both showed significant changes ( P 0.05) in comparison with normal control. (2) In 11 postmenopausal women treated with mHRT for 9～29 years,the levels of serum apoliprotein A1 (Apo A1) were increased from (1.42±0.21) g/L to (1.70±0.38) g/L,and the levels of serum lipoprotein (a) [Lp(a)] decreased from (0.24±0.13) g/L to (0.13±0.10) g/L. Both showed significant changes ( P 0.05). The levels of serum nitric oxide and Ang II did not change when compared with the normal control. (3) Except for the decreased serum levels of cholesterol in the postmenopausal women with ERT for 3 months,the levels of other lipids in the women with ERT or HRT were not found to be different from those before HRT." @default.
- W2380333719 created "2016-06-24" @default.
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- W2380333719 date "2004-01-01" @default.
- W2380333719 modified "2023-09-26" @default.
- W2380333719 title "The effects of short-and long-term hormone replacement therapy on serum lipids in the postmenopausal women" @default.
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