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- W2380335949 abstract "Objective To evaluate the analytical features of the new automated cardiac troponin I(cTnI) assay using enzyme-linked fluorescent assay(ELFA) technology and to obtain information about its utility in clinical studies. Methods The parameters links precision,analytical sensitivity,linearity range,recovery rate,calibration curve stability and interfere factors of the cTnI assay were determined. The comparison study was also performed versus enzyme-linked immunosorbent assay(ELISA). cTnI concentration was determined in 50 healthy individuals,62 patients without acute myocardial infarction(AMI) and 53 patients with AMI by ELFA. Results The total coefficient of variation was from 2.58 % to 4.82%. The minimal detection limit was 0.05μg/L. The linearity range was from 0.1 μg/L to 50μg/L. The mean recovery rate of dilution samples was 101.2%. The calibration curve was stable for at least fourteen days. Linear regression analysis showed a good correlation between the ELFA(Y) and ELISA(X) methods(Y=0.983X-0.148,r=0.996). Adding of high concentration of bilirubin,triglyceride or hemoglobin into samples did not interfere cTnI measurement by proposed method(P0.05). The statistical difference was much higher in patients with AMI compared with healthy individuals[(18.6±4.8)μg/L vs (0.068±0.014)μg/L,P0.01] or without AMI[(18.6±4.8)μg/L vs ( 0.055 ±0.021)μg/L,P0.01]. The cutoff value was 0.8μg/L for laboratory diagnosis of AMI,and sensitivity,specificity,accuracy,positive likelihood ratio and negative likelihood ratio were 91.4%, 93.8 %,92.9%,14.6 and 0.09,respectively. Conclusion The ELFA method is reliable,precise,fairly rapid and easy to perform. cTnI is a sensitive and specific marker of myocardial damage. This method is very useful and suitable for routine determinations of serum cTnI levels in clinical laboratory." @default.
- W2380335949 created "2016-06-24" @default.
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- W2380335949 date "2005-01-01" @default.
- W2380335949 modified "2023-09-24" @default.
- W2380335949 title "Determination of cardiac troponin I in serum by enzyme-linked fluorescent assay" @default.
- W2380335949 hasPublicationYear "2005" @default.
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