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- W2380341037 abstract "Objective:To evaluate the influence of IL-1β on the expression of MMP-2 of HFL cells in three-dimensional culture collagen gels.Methods:HFL cells were cultured in three-dimensional culture collagen gels.HFL cells were randomly divided into control and experimental groups.Cells of the control group were cultured in DMEM media without IL-1β.Cells of experimental groups were cultured in DMEM media with different concentrations of IL-1β(10,20 ng/ml),respectively.The phase contrast microscope was used to observe the morphology of cells.After 24,72 hours,harvested the supernatant,MMP-2 were detected by gelatin zymography.The proliferation of HFL cell stimulated by IL-1 β was examined by tetrazolium salt(MTT)assay.Results:In three-dimensional co-culture,HFL cells were growing in gel-culture,and it didn' t proliferate,and all of the cells were growing in singles.The expression of MMP-2 was different in different IL-1β concentration,and the stimulus was enhanced with the increasing of IL-1β doses.IL-1β can enhance HFL proliferation in a concentration-dependent Manner.The different concentrations of IL-1β had different effects on proliferation of HFL(P0.05),the proliferation ability was dose-time dependent.Conclusion:IL-1β may enhance the invasion and metastasis of lung cancer throughup-regulating the secretion and of MMP-2,and enhance HFL proliferation." @default.
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- W2380341037 date "2011-01-01" @default.
- W2380341037 modified "2023-09-23" @default.
- W2380341037 title "Influence of IL-1β on the expression of MMP-2 of human fetal lung fibroblasts cells" @default.
- W2380341037 hasPublicationYear "2011" @default.
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