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• W2380341330 abstract "HomeCirculation: Heart FailureVol. 9, No. 5Operating in the Dark Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBOperating in the DarkWhen Is Surgery Necessary for Left Ventricular Assist Device Hemolysis? Michael S. Kiernan, MD, SM and Jason N. Katz, MD, MHS Michael S. KiernanMichael S. Kiernan From the Division of Cardiology, Tufts Cardiovascular Center, Boston, MA (M.S.K.); and Division of Cardiology, University of North Carolina, Chapel Hill (J.N.K.). Search for more papers by this author and Jason N. KatzJason N. Katz From the Division of Cardiology, Tufts Cardiovascular Center, Boston, MA (M.S.K.); and Division of Cardiology, University of North Carolina, Chapel Hill (J.N.K.). Search for more papers by this author Originally published10 May 2016https://doi.org/10.1161/CIRCHEARTFAILURE.116.003141Circulation: Heart Failure. 2016;9:e003141The benefits of left ventricular assist device (LVAD) therapy in advanced heart failure are clear—device implantation can prolong patient survival, enhance functionality, and improve quality of life.1 Since US Food and Drug Administration approval of the first continuous-flow LVAD in 2008, utilization has grown rapidly, and now, >2500 devices are placed annually.1 Given the current epidemic of heart failure, this volume may only be scratching the surface. Current estimates suggest that there are upwards of 250 000 to 300 000 potential LVAD candidates in the United States alone.2 Despite technological and design advances, broader application of LVAD therapy remains limited in part by its relatively high rate of adverse events (AEs). Six-month freedom from rehospitalization is only 40%, whereas 70% of patients will experience an AE within the first year of support.1See Article by Levin et alIn this issue of Circulation: Heart Failure, Levin et al retrospectively described hemolytic events of HeartMate II (St. Jude Medical, Pleasanton, CA) patients at 2 large academic medical centers. Specifically, they compared outcomes for patients with hemolysis managed with surgical versus medical therapy, to determine the most effective strategy.3 Their findings were humbling. One-year freedom from stroke or death was 87.5% and 49.5% in the surgical and medical cohorts, respectively. Resolution of primary hemolysis without stroke, death, or recurrent hemolysis was only 44% in patients treated with medical therapy, compared to 63% in patients treated operatively. Even more sobering is the realization that the surgical cohort first failed medical therapy, and thus, the true treatment response to medical therapy alone was a paltry 29%. In summary, the principal finding was that for patients meeting the author’s definition of hemolysis, a surgical strategy (after failed medical intervention) resulted in less death or stroke than a medical strategy alone, as well as greater resolution of hemolysis.Hemolysis, a harbinger of LVAD thrombosis, remains one of the most common and feared complications of LVAD therapy, occurring in as many as 33% of patients in the first year after device implantation.4 In a multicenter analysis of hemolytic events from the Interagency Registry for Mechanically Assisted Circulatory Support, hemolysis was associated with an increased risk of thrombotic device malfunction, device exchange, and death.5 Management guidelines for hemolysis have been poorly vetted, and hence, recommendations are based largely on expert opinion.6 Nonetheless, several observational reports have recently demonstrated that medical therapy is associated with substantial treatment failure, and intensification of antithrombotic therapies may be associated with a high risk of complications, including intracranial hemorrhage.7–9From a medical perspective, heparin was the primary antithrombotic therapy utilized at these 2 centers to treat hemolysis and, similar to other reports, was largely ineffective.9,10 What is less clear is whether or not alternative antithrombotic regimens may have resulted in greater success. Data from other recent reports would suggest that the answer to this question would likely be no. When used to treat LVAD hemolysis, platelet glycoprotein IIb/IIIa inhibitors have been associated with high rates of bleeding and limited therapeutic efficacy.8 Additionally, although a small case series did describe a potentially favorable clinical response to the direct thrombin inhibitor, Bivalirudin, half of the patients ultimately had recurrent hemolysis after transitioning to oral Coumadin.11Early experiences with device exchange, on the other hand, were associated with high perioperative morbidity and mortality.12 Additionally, exchange of continuous-flow LVADs after prolonged hemolysis resulted in high rates of death.13 More recent reports, however, have revealed favorable outcomes after continuous-flow LVAD exchange and have reported 30-day mortality rates as low as 6.5%.14 In the initial report by Starling et al15, highlighting changes in temporal trends of LVAD thrombosis, mortality among patients treated medically was 48.2%, whereas those treated with urgent transplantation or device exchange had survival similar to patients without thrombosis. Furthermore, evolving surgical techniques, including a nonsternotomy approach to exchange, may be associated with decreased morbidity and mortality.16The study by Levin et al3 begins to address the large gap that still exists in our understanding of optimal hemolysis management. Although the risks associated with hemolytic events have been described previously, this analysis provides insight into outcomes associated with specific treatment strategies. Similar to the approach taken in the current report,3 LVAD exchange has been historically reserved for patients with refractory hemolysis or those with overt device malfunction and hemodynamic compromise.6 Although operative intervention has anecdotally become more commonplace, it has been hard to make a compelling case in favor of a potentially high-risk surgical strategy without comparative data, and clinicians have likely been reticent to pursue operative intervention without more rigorous guidance. The findings from this study vastly improve our understanding of the relative risks and benefits associated with device exchange versus watchful waiting. These data should assuage some of the fears that exist regarding earlier invasive management, even among patients who seemingly responded favorably to initial antithrombotic therapy. What remains unclear—and not addressed in this study—is the role of surgical intervention for less severe hemolysis.It is also evident that a “one-size fits all” strategy cannot be assumed for all hemolytic events. For instance, the pathophysiology of LVAD thrombosis is likely distinct for the HeartMate II and HVAD (HeartWare, Framingham, MA) devices. Although hemolysis has been described with the HVAD device,10 the preponderance of data comes from the HeartMate II population. Response to medical therapy is low with both devices,7–10 although it is unclear if they might respond differently to specific interventions. The onset of hemolysis with the HeartMate II is typically subacute over weeks,4 and the source of thrombus is commonly associated with pannus formation at the inflow or outflow bearings.17 In contrast, HVAD hemolytic events are typically more acute in presentation, and abnormalities in pump parameters are often present at the time of diagnosis because of laminar fibrin formation on the impeller itself.10,18 Long-term outcomes after hemolysis episodes in HVAD recipients also remain poorly characterized, and it is unknown whether the findings associated with watchful waiting in this article3 can be extrapolated to the HVAD population. Device-specific algorithms for monitoring, prevention, and long-term management are likely required.18It is troubling to note and important to emphasize that device exchange does not always equate to long-term cure, as >1 out of every 4 surgically treated patients had a future hemolytic event.3 Recurrent hemolysis is distressing to patients, caregivers, and providers alike. Factors triggering recurrent hemolysis remain unknown. Mechanical causes related to surgical technique have been reported.17,19 The authors did not think that recurrence was related to residual thrombus in the outflow graft or inflow cannula because hemolysis cleared in all patients and screening for additional thrombus was meticulously performed. They conclude that the risk of recurrence was more likely attributable to patient-level factors. It cannot be excluded, however, that mal-positioning of the inflow cannula or outflow graft, which often was unaddressed at the time of operative exchange, predisposed to delayed recurrence. Although a nonsternotomy approach has been associated with favorable outcomes among patients undergoing exchange, it is not clear whether this approach favorably impacts recurrence risk. A recent study from Columbia University did describe similar recurrence risk with either a sternotomy or subcostal exchange.20 These unanswered questions further underscore the need for prospective evaluation in larger LVAD populations.The nuances of the LVAD patient also affirm the need for individualized decision making, particularly as it relates to device strategy. Surgical exchange likely increases the risk of allosensitization, and its impact on transplant-related outcomes has been incompletely explored. The median time to hemolysis recurrence in a series of medically managed patients was 50 days9; therefore, if a short wait time to transplant is anticipated, an attempt to bridge patients to urgent transplantation may be a rational approach. For those unlikely to be transplanted soon, however, a lower threshold for exchange would seem pragmatic. In point of fact, a higher proportion of bridge-to-transplant patients in the current study were managed medically (59%) compared with surgically (41%).3Despite the merits of this study,3 it is important to remember that these findings are observational. With that come inherent limitations, including the inability to assign causality. The data were pooled from 2 large academic medical centers, and institutional variations in rates of thrombosis have already been described.19 These are likely, at least in part, because of differences in surgical technique, medical management strategies, and the rigor by which patients are routinely monitored. The authors do not provide details regarding center-specific outcomes as related to management strategies, and therefore, a center-specific effect cannot be excluded. It is difficult to differentiate the risk of hemolysis associated with device-, patient-, or center-level factors. It is also not possible to adjust for factors that influenced the decision to operate, and it is clear that patients who were managed surgically were inherently different than those treated medically. These differences may account partially for the subsequent risk of stroke or death. Finally, it remains unclear whether an interaction could exist among patient, device type, and the individual risk of thrombosis: could individual A have a higher risk of hemolysis with device B, while individual B has a higher risk with device A? As a result, among patients with recurrent hemolytic events, whether exchange to an alternative device is safe or if it reduces the risk of subsequent events has not been answered.The Interagency Registry for Mechanically Assisted Circulatory Support registry has been pivotal in describing the evolving risk of LVAD thrombosis over time.21 What Interagency Registry for Mechanically Assisted Circulatory Support lacks, however, is the granularity of data that would facilitate comparative effectiveness studies of hemolysis management strategies. The article by Levin et al highlights the need for collaborative data collection and prospective research to define best practices for the management of LVAD-related AEs. No randomized investigations to date have examined the benefits of specific interventions targeting a reduction of AEs in LVAD patients. The HeartMate 3 (Thoratec, Pleasanton, CA) is a new centrifugal continuous-flow LVAD with large gaps between the pump housing and perimeter of the rotor, as well as a biocompatible surface designed to minimize shear stress and blood trauma. Results of 50 patients who underwent implantation as part of the Conformite´ Européene Mark clinical trial remarkably had no episodes of hemolysis, pump thrombosis, or the need for exchange at 6 months.22 The larger US pivotal trial (Multi-center Study of MagLev Technology in Patients Undergoing MCS Therapy With HeartMate 3™ [MOMENTUM 3]) is ongoing (ClinicalTrials.gov Identifier: NCT02224755). Although the device industry focuses on technological advancements, further effort by clinical investigators should be placed on evaluating novel management strategies to mitigate the risk of AEs. The medical complexity and small sample size make conducting clinical trials in this population challenging, but our patients are depending on us to better define best practice. Results are forthcoming from the recently completed, industry-sponsored, multicenter Prevention of Heartmate II Pump Thrombosis (PREVENT) observational study investigating the risk of early HeartMate II thrombosis in 300 patients receiving standardized surgical and medical care (ClinicalTrials.gov Identifier: NCT02158403). Whether strategies targeting antiplatelet therapy or novel anticoagulants could minimize the risk of bleeding and thrombotic events also remains largely unexplored. The failure of Dabigatran to prevent thrombosis in patients with mechanical valves,23 as well as concerns regarding the reversibility of novel anticoagulants, have limited their current investigation as viable antithrombotic agents in LVAD patients. However, the recent US Food and Drug Administration approval of new reversal agents may provide greater opportunity to study these alternative therapies.Each patient presenting with hemolysis requires individualized decision making in the context of their history, implant strategy, and personal goals and values. The study by Levin et al3 is an important first step in establishing a more pragmatic algorithm for hemolysis management. The data support the evolving dogma that LVAD thrombosis is a surgical condition with perhaps a limited role for medical therapy in patients who are not surgical candidates, those who refuse repeat surgical intervention, or those in whom urgent transplantation is feasible. It is necessary to inform patients and caregivers regarding the high risk of recurrence, although stroke-free survival rates after LVAD exchange seem promising when performed at experienced centers. Reduction in LVAD-related AEs will permit expansion of this life-saving and restorative technology to a broader and potentially less sick population. So that we are no longer operating in the dark, and novel methods to improve granular data collection, enhance collaboration, and facilitate comparative effectiveness research are critical.DisclosuresDr Kiernan has received sponsored travel reimbursement from Thoratec, Inc (<$10K). J.N. Katz has received sponsored travel reimbursement and research support (<$10K) from Thoratec, Inc.FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to Michael S. Kiernan, MD, SM, Tufts Medical Center, Boston, MA 02111. E-mail [email protected]References1. Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED, Myers SL, Miller MA, Baldwin JT, Young JB. Seventh INTERMACS annual report: 15,000 patients and counting.J Heart Lung Transplant. 2015; 34:1495–1504. doi: 10.1016/j.healun.2015.10.003.CrossrefMedlineGoogle Scholar2. Miller LW, Guglin M. Patient selection for ventricular assist devices: a moving target.J Am Coll Cardiol. 2013; 61:1209–1221. doi: 10.1016/j.jacc.2012.08.1029.CrossrefMedlineGoogle Scholar3. Levin AP, Saeed O, Willey JZ, Levin CJ, Fried JA, Patel SR, Sims DB, Nguyen JD, Shin JJ, Topkara VK, Colombo PC, Goldstein DJ, Naka Y, Takayama H, Uriel N, Jorde UP. Watchful waiting in continuous-flow left ventricular assist device patients with ongoing hemolysis is associated with an increased risk for cerebrovascular accident or death.Circ Heart Failure. 2016; 9:e002896. doi: 10.1161/CIRCHEARTFAILURE.115.002896.LinkGoogle Scholar4. Cowger JA, Romano MA, Shah P, Shah N, Mehta V, Haft JW, Aaronson KD, Pagani FD. Hemolysis: a harbinger of adverse outcome after left ventricular assist device implant.J Heart Lung Transplant. 2014; 33:35–43. doi: 10.1016/j.healun.2013.08.021.CrossrefMedlineGoogle Scholar5. Katz JN, Jensen BC, Chang PP, Myers SL, Pagani FD, Kirklin JK. A multicenter analysis of clinical hemolysis in patients supported with durable, long-term left ventricular assist device therapy.J Heart Lung Transplant. 2015; 34:701–709. doi: 10.1016/j.healun.2014.10.002.CrossrefMedlineGoogle Scholar6. Goldstein DJ, John R, Salerno C, Silvestry S, Moazami N, Horstmanshof D, Adamson R, Boyle A, Zucker M, Rogers J, Russell S, Long J, Pagani F, Jorde U. Algorithm for the diagnosis and management of suspected pump thrombus.J Heart Lung Transplant. 2013; 32:667–670. doi: 10.1016/j.healun.2013.05.002.CrossrefMedlineGoogle Scholar7. Stulak JM, Dunlay SM, Sharma S, Haglund NA, Davis MB, Cowger J, Shah P, Masood F, Aaronson KD, Pagani FD, Maltais S. Treatment of device thrombus in the HeartWare HVAD: Success and outcomes depend significantly on the initial treatment strategy.J Heart Lung Transplant. 2015; 34:1535–1541. doi: 10.1016/j.healun.2015.10.020.CrossrefMedlineGoogle Scholar8. Tellor BR, Smith JR, Prasad SM, Joseph SM, Silvestry SC. The use of eptifibatide for suspected pump thrombus or thrombosis in patients with left ventricular assist devices.J Heart Lung Transplant. 2014; 33:94–101. doi: 10.1016/j.healun.2013.11.002.CrossrefMedlineGoogle Scholar9. Upshaw JN, Kiernan MS, Morine KJ, Kapur NK, DeNofrio D. Incidence, management, and outcome of suspected continuous-flow left ventricular assist device thrombosis.ASAIO J. 2016; 62:33–39. doi: 10.1097/MAT.0000000000000294.CrossrefMedlineGoogle Scholar10. Najjar SS, Slaughter MS, Pagani FD, Starling RC, McGee EC, Eckman P, Tatooles AJ, Moazami N, Kormos RL, Hathaway DR, Najarian KB, Bhat G, Aaronson KD, Boyce SW; HVAD Bridge to Transplant ADVANCE Trial Investigators. An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial.J Heart Lung Transplant. 2014; 33:23–34. doi: 10.1016/j.healun.2013.12.001.CrossrefMedlineGoogle Scholar11. Sylvia LM, Ordway L, Pham DT, DeNofrio D, Kiernan M. Bivalirudin for treatment of LVAD thrombosis: a case series.ASAIO J. 2014; 60:744–747. doi: 10.1097/MAT.0000000000000122.CrossrefMedlineGoogle Scholar12. Schechter MA, Daneshmand MA, Patel CB, Blue LJ, Rogers JG, Milano CA. Outcomes after implantable left ventricular assist device replacement procedures.ASAIO J. 2014; 60:44–48. doi: 10.1097/MAT.0000000000000011.CrossrefMedlineGoogle Scholar13. Ravichandran AK, Parker J, Novak E, Joseph SM, Schilling JD, Ewald GA, Silvestry S. Hemolysis in left ventricular assist device: a retrospective analysis of outcomes.J Heart Lung Transplant. 2014; 33:44–50. doi: 10.1016/j.healun.2013.08.019.CrossrefMedlineGoogle Scholar14. Moazami N, Milano CA, John R, Sun B, Adamson RM, Pagani FD, Smedira N, Slaughter MS, Farrar DJ, Frazier OH; HeartMate II Investigators. Pump replacement for left ventricular assist device failure can be done safely and is associated with low mortality.Ann Thorac Surg. 2013; 95:500–505. doi: 10.1016/j.athoracsur.2012.09.011.CrossrefMedlineGoogle Scholar15. Starling RC, Moazami N, Silvestry SC, Ewald G, Rogers JG, Milano CA, Rame JE, Acker MA, Blackstone EH, Ehrlinger J, Thuita L, Mountis MM, Soltesz EG, Lytle BW, Smedira NG. Unexpected abrupt increase in left ventricular assist device thrombosis.N Engl J Med. 2014; 370:33–40. doi: 10.1056/NEJMoa1313385.CrossrefMedlineGoogle Scholar16. Schechter MA, Patel CB, Blue LJ, Welsby I, Rogers JG, Schroder JN, Milano CA. Improved early survival with a nonsternotomy approach for continuous-flow left ventricular assist device replacement.Ann Thorac Surg. 2015; 99:561–566. doi: 10.1016/j.athoracsur.2014.08.032.CrossrefMedlineGoogle Scholar17. Uriel N, Han J, Morrison KA, Nahumi N, Yuzefpolskaya M, Garan AR, Duong J, Colombo PC, Takayama H, Thomas S, Naka Y, Jorde UP. Device thrombosis in HeartMate II continuous-flow left ventricular assist devices: a multifactorial phenomenon.J Heart Lung Transplant. 2014; 33:51–59. doi: 10.1016/j.healun.2013.10.005.CrossrefMedlineGoogle Scholar18. Jorde UP, Aaronson KD, Najjar SS, Pagani FD, Hayward C, Zimpfer D, Schlöglhofer T, Pham DT, Goldstein DJ, Leadley K, Chow MJ, Brown MC, Uriel N. Identification and management of pump thrombus in the HeartWare left ventricular assist device system: a novel approach using log file analysis.JACC Heart Fail. 2015; 3:849–856. doi: 10.1016/j.jchf.2015.06.015.CrossrefMedlineGoogle Scholar19. Taghavi S, Ward C, Jayarajan SN, Gaughan J, Wilson LM, Mangi AA. Surgical technique influences HeartMate II left ventricular assist device thrombosis.Ann Thorac Surg. 2013; 96:1259–1265. doi: 10.1016/j.athoracsur.2013.05.081.CrossrefMedlineGoogle Scholar20. Levin AP, Uriel N, Takayama H, Mody KP, Ota T, Yuzefpolskaya M, Colombo PC, Garan AR, Dionizovik-Dimanovski M, Sladen RN, Naka Y, Jorde UP. Device exchange in HeartMate II recipients: long-term outcomes and risk of thrombosis recurrence.ASAIO J. 2015; 61:144–149. doi: 10.1097/MAT.0000000000000170.CrossrefMedlineGoogle Scholar21. Kirklin JK, Naftel DC, Kormos RL, Pagani FD, Myers SL, Stevenson LW, Acker MA, Goldstein DL, Silvestry SC, Milano CA, Baldwin JT, Timothy Baldwin J, Pinney S, Eduardo Rame J, Miller MA. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device.J Heart Lung Transplant. 2014; 33:12–22. doi: 10.1016/j.healun.2013.11.001.CrossrefMedlineGoogle Scholar22. Netuka I, Sood P, Pya Y, Zimpfer D, Krabatsch T, Garbade J, Rao V, Morshuis M, Marasco S, Beyersdorf F, Damme L, Schmitto JD. Fully magnetically levitated left ventricular assist system for treating advanced HF: a multicenter study.J Am Coll Cardiol. 2015; 66:2579–2589. doi: 10.1016/j.jacc.2015.09.083.CrossrefMedlineGoogle Scholar23. Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappetein AP, Mack MJ, Blatchford J, Devenny K, Friedman J, Guiver K, Harper R, Khder Y, Lobmeyer MT, Maas H, Voigt JU, Simoons ML, Van de Werf F; RE-ALIGN Investigators. Dabigatran versus warfarin in patients with mechanical heart valves.N Engl J Med. 2013; 369:1206–1214. doi: 10.1056/NEJMoa1300615.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Levesque A, Lewin A, Rimsans J, Sylvester K, Coakley L, Melanson F, Mallidi H, Mehra M, Givertz M and Connors J (2019) Development of Multidisciplinary Anticoagulation Management Guidelines for Patients Receiving Durable Mechanical Circulatory Support, Clinical and Applied Thrombosis/Hemostasis, 10.1177/1076029619837362, 25, (107602961983736), Online publication date: 1-Jan-2019. Rimsans J, Sylvester K and Connors J (2016) Direct Thrombin Inhibitor for LVAD Thrombosis: A Closer Look, Clinical and Applied Thrombosis/Hemostasis, 10.1177/1076029616672583, 23:5, (405-409), Online publication date: 1-Jul-2017. Ghbeis M, Vander Pluym C and Thiagarajan R (2021) Hemostatic Challenges in Pediatric Critical Care Medicine—Hemostatic Balance in VAD, Frontiers in Pediatrics, 10.3389/fped.2021.625632, 9 May 2016Vol 9, Issue 5 Advertisement Article InformationMetrics © 2016 American Heart Association, Inc.https://doi.org/10.1161/CIRCHEARTFAILURE.116.003141PMID: 27166249 Originally publishedMay 10, 2016 Keywordsstrokeheart failurethrombosisassisted circulationfreedomEditorialsdeathPDF download Advertisement SubjectsCardiomyopathyCardiovascular SurgeryHeart FailureTransplantation" @default.
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