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- W2380342813 abstract "Objective To investigate atropine-induced heart rate changes during propofol anesthesia.Methods Seventy-five patients were randomly assigned to three groups:P0 group did not receive propofol;P4 and P8 received IV propofol 1.50mg/kg,2.50mg/kg respectively and vecuronim 0.15mg/kg.After tracheal intubation,anesthesia was maintained with propofol 4mg·kg-1·h-1,8mg·kg-1·h-1 respectively and 50% N2O.When a stable hemodynamic state was obtained,all patients received incremental doses of atropine 5μg/kg at every 2mins,and heart rate response was observed.Results When cumulative atropine was 10μg/kg,HR in three groups were significantly different from baseline values(t=4.77,3.32,2.58,P0.05);when cumulative atropine was 15μg/kg ,atropine-induced heart rate changes of P4 and P8 were significantly different from baseline values respectively(t=6.67,4.07,P0.05);when cumulative atropine was 10μg/kg,the changes of HR in group P4 and P8 were significantly different from those in group P0 respectively(t=2.59,4.26,P0.05);when cumulative atropine was 15μg/kg,atropine-induced heart rate changes between P4 and P8 were significantly different(t=3.07,P0.05) .Conclusions The HR response to IV atropine is attenuated during propofol anesthesia,which is attributable to propofol-induced dominance of parasympathetic nervous system,suppression of the sympathetic nervous system and baroreflex." @default.
- W2380342813 created "2016-06-24" @default.
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- W2380342813 date "2008-01-01" @default.
- W2380342813 modified "2023-09-26" @default.
- W2380342813 title "Atropine-induced heart rate changes during propofol anesthesia" @default.
- W2380342813 hasPublicationYear "2008" @default.
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