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- W2380349741 abstract "Objective To explore Aprotinin enhancing release of endogenous interleukin-10(IL-10),and dose-effective relation during extracorporeal circulation(ECC)in children.Methods Patients were selected according to standards,and randomly divided into six groups:control group(group A 1,n=15),low-dose aprotinin group(group B 1,n=15),high-dose aprotinin group(group C 1,n=15),and dexamethasone group(group A 2,n=20),dexamethasone + small-dose aprotinin group(group B 2,n=20),dexamethasone+full-dose aprotinin group(group C 2,n=20).Serum level of IL-10 was measured by enzyme-linked immunosorbent assay technique before operation,30 minutes after ECC,and at 2 hours,24 hours,7 days after the end of ECC.Results A significant increase(P0.01)of IL-10 concentration occurred in all groups at 30 minutes after ECC,and at 2 hours after the end of ECC.Moreover,when group B 1 and group C 1 compared with A 1,group B 2 and group C 2 compared with A 2,and group C 1 compared with B 1,group C 2 compared with B 2,there were statistical significances in the increase of IL-10(P0.01).The hospital stay of group A 1 and group B 1 prolonged markedly(P0.05).Conclusion Aprotinin can enhance the release of endogenous IL-10,and the effect of Aprotinin has positive correlation with dosage." @default.
- W2380349741 created "2016-06-24" @default.
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- W2380349741 date "2005-01-01" @default.
- W2380349741 modified "2023-09-23" @default.
- W2380349741 title "Aprotinin enhancing release of endogenous interleukin-10 during extracorporeal circulation in children" @default.
- W2380349741 hasPublicationYear "2005" @default.
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