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- W2380352296 abstract "Objective:To determine and evaluate the changes of NO and NOS in serum after traumatic brain injury and relationship between them and brain edema,and at the same time to detect the changes of NO and NOS in serum and the relationship between these changes and positive NOS neurons.Method:thirty-six SD rats were used and divided into two groups: the normal control and the operation group.The cerebral contusion model was produced by dropping weight.The traumatic brain injury model was built successfully and contents of NO and NOS in cerebral contusion tissue were measured,so were brain water contents and changes of NO and NOS in serum.Results:(1)Data of the normal control and the operation groups were significantly different(P0.05).(2) NO values of the traumatic right hemisphere were significantly higher than those of the normal control group,so were brain water contents and NO in serum(P0.05).NOS activity of the traumatic hemisphere was higher than that of the operation group(P0.05),so was in serum.Conclusions:The results of this study suggests that No and NOS in rats after tbe injury increase,which is related to the occurrence of cerebral edema,by prompt early clinical treatment of brain injury with addition of exogenous NOS scavenger,in conjunction with dehydrating agents,it is possible to reduce brain edema in secondary injury." @default.
- W2380352296 created "2016-06-24" @default.
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- W2380352296 date "2012-01-01" @default.
- W2380352296 modified "2023-09-23" @default.
- W2380352296 title "Experimental brain injury in rat plasma NO content and NOS activity and its significance" @default.
- W2380352296 hasPublicationYear "2012" @default.
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