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- W2380360013 abstract "Objective Objective To investigate the effects of diltiazem on renal function in patients who underwent cardiopulmonary bypass. Methods Forty cases of ASA grade Ⅱ~Ⅲ undergoing replacement of valve under cardiopulmonary bypass were divided into two groups:Treated group(n=20)receiving a continuous intravenous infusion of diltiazem at 2 μg/(kg·min) from the beginning of CPB and continue for 1.5 hours.Control group(n=20)received no diltiazem.Cr clear ratio(CCR),urine-α_1-microglobulin,urine-β_2-microglobulin were measured before anesthesia,the duration of CPB,4 hours after CPB and 12 hours after CPB.Results ①Before anesthesia there is no remarkable difference between two groups in CCR,u-α_1-MG and u-β_2-MG(P0.05).②In the end of CPB,4 hours after CPB,the level of CCR obviously decreased in the two groups respectively(P0.05),and it was obviously lower in Control group than Treatment group(P(0.05)),but it came back to the base line until 12 hours after CPB in two groups(P0.05).③In the duration of CPB,4 hours after CPB,12 hours after CPB,the levels of u-α_1-MG and u-β_2-MG obviously increased in the two groups respectively(P0.05),and it was obviously lower in Treatment group than Control group(P0.05).Conclusion Cardiopulmonary bypass have a negative effect on renal function.Diltiazem has protection on renal function in patients who undergoing cardiopulmonary bypass." @default.
- W2380360013 created "2016-06-24" @default.
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- W2380360013 date "2006-01-01" @default.
- W2380360013 modified "2023-09-25" @default.
- W2380360013 title "A Clinical Investigation of Diltiazem's Effects on Renal Function in Undergoing Cardiopulmonary Bypass" @default.
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