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- W2380367105 abstract "Objective:To investigate the effect of 5-Aza-2′-deoxycytidine(5-Aza-CdR) on human leukocyte antigen C(HLA-C) expression and the relationship with DNA methyltransferase 1(DNMT1) in gastric cancer cells.Methods:The gastric cancer cells BCG823 cultured in medium containing 10 μmol/L 5-Aza-CdR(final concentration) were as experiment group.The untreated gastric cancer cell were as control group.The transcripts of HLA-C and DNMT1 genes were detected by semi-quantitative reverse transcription-PCR(RT-PCR).The methylation level of HLA-C was analyzed by methylation-specific PCR(MSP).Results:The expression of DNMT1 mRNA in BGC823 cells treated with 5-Aza-CdR were obvious less than in untreated cells.The DNA hypermethylation in CpG island of HLA-C gene was reversed and leaded to up-regulation of HLA-C transcripts.There was the statistical significance between the control and experiment group in the expression of HLA-C mRNA analyzed by Gel-Pro Analyzer(P0.01).Conclusions:5-Aza-CdR treatment can lead to DNA demethylation of HLA-C through inhibiting the expression of DNMT1,and then up-regulating the expression of HLA-C mRNA." @default.
- W2380367105 created "2016-06-24" @default.
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- W2380367105 date "2010-01-01" @default.
- W2380367105 modified "2023-09-24" @default.
- W2380367105 title "Effect of 5-Aza-2′-deoxycytidine on human leukocyte antigen C expression in gastric cancer cells" @default.
- W2380367105 hasPublicationYear "2010" @default.
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