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- W2380367885 abstract "Objective To investigate cytotoxic and radiosensitizing effect of Artemisinin on cervical carcinoma cell line HeLa.Methods In order to measure the optimized effective time,cytotoxic effect of Artemisinin on HeLa cell line was investigated with MTT assay.The radiosensitization effect of different doses and different treatment duration of Artemisinin on HeLa cell line were evaluated by MTT test,the SER is 1.17 and radiosensitizing effect was measured with multi-target single hit model through SER of HeLa cell.Cell cycles in different groups were calculated by flow cytometry.Results The 50% inhibition concentration of Artemisinin interacted with HeLa cells for 24 h is 600.19 nmol/ml,and for 48 h is 160.71nmol/ml.The HeLa cells’surival ratio is 93.51%、91.87%、and 87.28% after adding Atemisinin of 110.69nmol/ml and 1Gy radiation exposure.There are three groups:the chemotherapy only group,the radiotherapy only group and the combination group.The result of the cell cycles showed that cells in G2/M period decreased in the combination group.Conclusion Artemisinin has radiosensitization effect on cervical carcinoma HeLa cells,whichshows dose and time dependent.Artemisinin can inhibit the G2/M block by ionizing radiation." @default.
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- W2380367885 date "2010-01-01" @default.
- W2380367885 modified "2023-09-24" @default.
- W2380367885 title "Cytotoxic Effect and Radiation Enhancement of Artemisinin in Uterine Cervical Carcinoma Cell Line HeLa" @default.
- W2380367885 hasPublicationYear "2010" @default.
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