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- W2380371496 abstract "Objective:To discuss the effect of BushenZengxiao Fluid based on the principle of tonifying kidney essence mainly on expression of p53 mRNA、Caspase-3 protein in spleen tissue of mice with radiation damage.Methods:The mice were divided into the control group,pathological model group,large、middle and small dosage group,positive medicine group randomly. Each was given treatment eight days by gastrogavage.After seven days of treatment,all the mice except that of the control group were exposed to the~(60)Coγray to make the radiation damage model.One day later each spleen tissue was taken out to examine the expression of p53 mRNA by hybridization method and that of the Caspase-3 protein by immunohistochemical method. Results:Analysis through the pathological image analysis system shows that each medication group can increase the expression of p53 mRNA,besides,they show a significant difference compared with the model group(P0.01);each medication group can decrease the expression of the Caspase-3 protein,moreover,large and middle dosage group show a significant difference compared with the model group(P0.01).Conclusion:BushenZengxiao Fluid can promote the repair after radiation damage by regulating and controlling the expression of p53 mRNA and that of caspase-3 protein which are closely related to the damage of the DNA." @default.
- W2380371496 created "2016-06-24" @default.
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- W2380371496 date "2008-01-01" @default.
- W2380371496 modified "2023-09-22" @default.
- W2380371496 title "Effect of BushenZengxiao Fluid on expression of p53 mRNA、Caspase-3 protein in the spleen tissue of mice with radiation damage" @default.
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