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- W2380385890 abstract "Objective To study the protective effect of dihydromyricetin against the renal oxidative damage of impaired glucose tolerance rats.Methods Animal model of impaired glucose tolerance rats was created by intraperitoneal injection of D-galactose.After 8 weeks intraperitoneal injection of dihydromyricetin(experimental group),fasting blood glucose,two-hour postprandial blood glucose,serum insulin,microalbuminuia(mAlb)and blood urea nitrogen(BUN),the activity of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px),the content of malondiadehyde(MDA) as well as renal DNA trailing rate were measured.Results Compared with the model group,dihydromyricetin significantly reduced the level of tow-hour postprandial blood glucose,insulin and insulin resistance index and increased the activity of SOD in the kidney(P0.05) but except for GSH-Px(P0.05);Dihydromyricetin also decreased the content of MDA,microalbuminuia and DNA trailing rate(P0.05).Conclusion Dihydromyricetin significantly improves impaired glucose tolerance and has a protective effect against early renal damage,which may be associated with improvement of antioxidative capability in the kidney." @default.
- W2380385890 created "2016-06-24" @default.
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- W2380385890 date "2009-01-01" @default.
- W2380385890 modified "2023-09-24" @default.
- W2380385890 title "The protective effects of dihydromyricetin against oxidative damage on the kidney of impaired glucose tolerance rats" @default.
- W2380385890 hasPublicationYear "2009" @default.
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