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- W2380392023 abstract "Objective To detect the expression of survivin,p16 and microvessel density(MVD)in carcinogenesis of colorectal mucosa,and analyze the clinic significance.MethodsThe expression of survivin,p16 and MVD in 15 specimens of normal colorectal mucosa,15 specimens of inflammatory polyps,23 specimens of adenomatous polyps,48 specimens of colorectal carcinoma were tested by SABC immunohistochemical staining.Results(1)The positive rates of survivin in normal colorectal mucosa,inflammatory polyps,adenomatous polyps and colorectal carcinoma showed a increasing trend.Positive rate in adenomatous polyps and colorectal carcinoma was significantly higher than that in normal colrectal mucosa.The positive rates of p16 showed a descending trend.Positive rate in colorectal carcinoma was significantly lower than that in normal colorectal mucosa.The MVD showed a increasing trend.MVD in adenomatous polyps and colorectal carcinoma was significantly higher than that in normal colorectal mucosa.(2)survivin was related to differentiation and Dukes stage of colorectal carcinoma,independent of age,gender,tumor site.MVD was associated with Dukes stage.There was no correlation between p16 and clinicopathologic features mentioned above.(3)There was negative correlation between survivin and p16,also between p16 and MVD.Positive correlation was found between survivin and MVD.The MVD in survivin-/p16+ group was significantly lower than survivin+/p16-group and survivin+/p16+ group,and exhibited a descending trend with survivin-/p16-group.ConclusionHigh expression of survivin,increasing of MVD,and loss expression of p16 may play an important role in carcinogenesis of colorectal mucosa,and they can be used as important mark for early diagnosis of colorectal carcinoma.Both survivin and p16 involve in the regulation of tumor blood vessels." @default.
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- W2380392023 date "2008-01-01" @default.
- W2380392023 modified "2023-09-27" @default.
- W2380392023 title "Expression of survivin p16 and Microvessel Density in Carcinogenesis of Colorectal Mucosa and Their Clinic Significance" @default.
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