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- W2380398350 abstract "OBJECTIVE:To investigate the effect of proteasome inhibitor MLN2238on human cervical cancer HeLa cell growth inhibition,it's radiosensitivity and its mechanism.METHODS:HeLa cell growth inhibitory effect was detected by CCK-8;colony formation assay was used to detect the radiosensitivity changes;We used the flow cytometry to detect the rate of apoptosis;Mitochondrial fluorescent probe imaging was used to detect the changes in mitochondrial activity;Determination of protein expression in cells were detected by Western Blot method.RESULTS : The results showed that MLN2238significantly inhibited HeLa cells,with the inhibition rate of 3.95% by 0.05μmol/L,14.89% by 0.1μmol/L, 29.37%by 0.5μmol/L,38.95%by 1μmol/L,54.44%by 5μmol/L,70.52%by 10μmol/L,81.76%by 30μmol/L,and its effect was dose-dependent,F=1172.02,P0.001;MLN2238(0.1μmol/L)showed the radiosensitizing effects on HeLa cells,and the sensitizing enhancement ratio(SER)was 1.40.MLN2238interacts with X-ray in HeLa cells.The apoptosis rate of the control group was(2.64±0.07)%,the MLN2238group was(2.76±0.38)%,the 4Gy radiation single group was(9.50±0.14)%,the 8Gy radiation single group was(21.04±0.04)%,the 4Gy combination group was(11.12±0.19)%,the 8Gy combination group was(26.18±0.35)%,the apoptosis rate was increased,the difference was statistically significant(F=20.23,P=0.002 2).0.1μmol/L MLN2238aggravated the menbrane injury while it can increase apoptosis,the combination of X-rays and MLN2238can increase the expression of protein Bcl-2and Bax.CONCLUSION:MLN2238can inhibite HeLa cells growth and has radiosensitizing effect on HeLa cells,which may be mediated through the mitochondrial pathway of apoptosis." @default.
- W2380398350 created "2016-06-24" @default.
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- W2380398350 date "2014-01-01" @default.
- W2380398350 modified "2023-09-23" @default.
- W2380398350 title "Radiation sensitization MLN2238 on human HeLa cells of cervical cancer" @default.
- W2380398350 hasPublicationYear "2014" @default.
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