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- W2380399013 abstract "Objective To investigate the association between TIMP1 gene polymorphic expression and susceptibility to aggressive periodontitis.Methods Gingiva from 36 patients with severe aggressive periodontitis and 35 matched control individuals were collected.DNA was extracted from gingival by phenol-chloroform standard,and proteinase K was used to digest proteins. Methylation-sensitive restriction PCR was used to determine whether TIMP1 gene is methylated or not.Different expression of the TIMP1 gene between patients and controlled groups were analyzed.Results Property of unmethylated TIPM1 gene linked to two X chromosome in female severe aggressive periodontitis patients is higher than that of the controlled group.The difference was statistically significant.Conclusion These data indicate that polymorphic expression of TIMP1 gene may be associated with the susceptibility to aggressive periodontitis." @default.
- W2380399013 created "2016-06-24" @default.
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- W2380399013 date "2006-01-01" @default.
- W2380399013 modified "2023-09-23" @default.
- W2380399013 title "Study of Epigenetics in Aggressive Periodontitis Gingival" @default.
- W2380399013 hasPublicationYear "2006" @default.
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