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- W2380426620 abstract "Objective To study the effects of acrylonitrile(ACN) on sex hormone of rats and mice and to explore the mechanism of ACN on male reproductive toxicity. Methods Male mice were daily given ACN by gavage 5 times a week for 8 weeks at doses of 0,6^0, 12^0 or 24^0 mg/kg body weight; rats were daily administrated ACN ip. 5 times a week for 13 weeks at doses of 0,7^5,15^0 or 30^0 mg/kg body weight, respectively. Levels of testosterone(T)and estradiol(E_2)in sera were measured by radioimmunoassay(RIA). Neonate female SD rats(22~{25 d}) were randomly divided into 5 groups: negative control group(solution)and positive control group(β-estradiol,single ip.30 μg/kg),other three groups administrated with ACN single ip.at doses of 5.0,15.0 or 30.0 mg/kg to evaluate whether ACN had estrogen-like activity by uteri-weighing. Results T levels in sera of all treated groups(ICR mice and Kunming mice)were lower than those in control.There was very significant difference in T level between the highest-dose group and control group for ICR mice(P0.01),and significant difference in T level of sera between the middle-dose group and control group for Kunming mice(P0.05).E-2 level was significantly increased in the lowest-dose group after SD rats was treated for 13 weeks(P0.05).The levels of T and E_2 of sera in the highest-dose group were markedly lower than that in the lowest-dose group,but there was no significant difference between the highest-dose group and control group.There was no significant difference in uteri weight between ACN treated group and negative control group after neonate female SD rats were treated with ACN single ip. Conclusions These results show that ACN could induce changes in sexual hormone levels in sera of male mice and rats.It indicates that ACN may affect reproductive endocrinium of male mice and rats.ACN has no estrogen-like activity." @default.
- W2380426620 created "2016-06-24" @default.
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- W2380426620 date "2005-01-01" @default.
- W2380426620 modified "2023-09-27" @default.
- W2380426620 title "Effects of Acrylonitrile on Levels of Sexual Hormone in Sera of Rats and Mice" @default.
- W2380426620 hasPublicationYear "2005" @default.
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