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- W2380427318 abstract "Objective To investigate the dynamic expression and significance of the vasoactive intestinal peptide receptor 2(VIPR2) mRNA at the posterior pole of the eye in high myopia.Methods Thirty one-day-old,healthy,yellow leghorn chickens were randomly chosen for the study.For 15 chickens,the experimental group,a method of form deprivation was used where the right eyes were covered continuously for 1 week,2 weeks or 4 weeks. The other 15 chickens acted as a control group. Retinoscopy and A-scan ultrasonography were used to measure refractive status and axial length of the eye.The dynamic expression of VIPR2 mRNA at the posterior pole of the eye was tested with RT-PCR.Results The experimental eyes quickly changed from pre-experimental hypermetropia to high myopia during the experimental period,and the severity of myopia and axial length increased relative to the period of form deprivation. The expression of VIPR2 mRNA and the levels decreased over time for both groups. The expression of VIPR2 mRNA in the experimental groups was significantly up-regulated compared to the control group(P0.01).Conclusion Form deprivation induces axial myopia.The increase in the severity of myopia was related to the period of form deprivation.The expression of VIPR2 mRNA at the posterior pole of the eye of FDM chicken models was up-regulated significantly.VIPR2 may play an important role in the formation and development of myopia." @default.
- W2380427318 created "2016-06-24" @default.
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- W2380427318 date "2006-01-01" @default.
- W2380427318 modified "2023-09-24" @default.
- W2380427318 title "Dynamic expression of VIPR2 mRNA in form deprivation myopia" @default.
- W2380427318 hasPublicationYear "2006" @default.
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