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- W2380431312 abstract "Objective To investigate the changes of Gi2 proteins of chronic morphine addiction rats with the technique of immunohistochemistry in five brain regions(ventral tegmental area, nucleus accumbens, prefrontal cortex, hippocampus and locus coeruleus).Methods Eighteen adult male Sprague-Dawley rats were divided randomly into three groups(n=6) chronic morphine dependent group,chronic abstinent group and chronic control group.Chronic dependent groups and abstinent group were administered with morphine by intraperitoneal injection till morphine dependent models were founded.The rats in abstinent groups were induced withdrawal sydromes with naloxone 5mg/kg for 30min.The rats in control group were injected with Saline.All rats were sacrificed by decapitation.The coronal sections of discrete brain regions (ventral tegmental area,nucleus accumbens,prefrontal cortex,locus coeruleus, hippocampus)were cut.The relative concentrations of Gi2 protein were detected by the technique of immunohistochemistry.Results The Gi2 protein didn't significantly change in others brain regions(P0.05)in chronic morphine dependent group and chronic abstinent group Gi2 protein were significantly more decrease in nucleus accumbens (P0.01)and significantly more increase in locus coeruleus(P0.05) than the chronic control group. Compared with the chronic control group,other brain regions didn't find the changes(P0.05).Conclusion The morphine-induced differential changes in Gi2 protein levels may reflect changes in gene expression and the result in changes of Gi2 protein may affect signal transduction pathways in morphine dependent animals.Maybe that is the molecular mechanism of oipioid tolerance and dependence." @default.
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- W2380431312 date "2006-01-01" @default.
- W2380431312 modified "2023-09-25" @default.
- W2380431312 title "Alterations of G_(i2) proteins in brain regions of morphine tolerant and dependent rats" @default.
- W2380431312 hasPublicationYear "2006" @default.
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