Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380431390> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2380431390 abstract "Objective To explore the change of hippocampal neurons cholinergic receptor in rats with vascular dementia(VD).Methods VD rat models were established by employing improved method of Pulsinelli's four-vessel occlusion.1 month later,the abilities of learning and memory of VD models were tested by Morris water maze.The activities of acetylcholinesterase (AChE) in plasma and hippocampus were detected by the improved Ellman's colorimetric methods.The expressions of hippocampal nicotinic acetylcholine receptor (nAChR) subunits α3,α4 and α7 proteins and mRNA were detected respectinely by Western Blotting and RT-PCR,respectively.The results were compared with sham operation group.Results Compared to the sham operation group,the escape latency of Morris water maze test and the first time crossing platform in VD group were significantly prolonged,the number of crossing platform was decreased (all P0.01).The activity in plasma AChE was significantly lower;while,in hippocampus was significantly higher(all P0.05).The expression of hippocampal nAChR subunits α3,α4 and α7 proteins and α3,α7 mRNA were obviously reduced (P0.05～0.01);while,the expression of nAChR α4 mRNA was increased (P0.01).Conclusion Lower expression of hippocampal neurons nAChR may be the basis of impairment of the cognition function in VD rats." @default.
- W2380431390 created "2016-06-24" @default.
- W2380431390 creator A5047258778 @default.
- W2380431390 date "2009-01-01" @default.
- W2380431390 modified "2023-09-22" @default.
- W2380431390 title "Change of hippocampal neurons cholinergic receptor in rats with vascular dementia" @default.
- W2380431390 hasPublicationYear "2009" @default.
- W2380431390 type Work @default.
- W2380431390 sameAs 2380431390 @default.
- W2380431390 citedByCount "0" @default.
- W2380431390 crossrefType "journal-article" @default.
- W2380431390 hasAuthorship W2380431390A5047258778 @default.
- W2380431390 hasConcept C126322002 @default.
- W2380431390 hasConcept C134018914 @default.
- W2380431390 hasConcept C148762608 @default.
- W2380431390 hasConcept C15744967 @default.
- W2380431390 hasConcept C169760540 @default.
- W2380431390 hasConcept C170493617 @default.
- W2380431390 hasConcept C181199279 @default.
- W2380431390 hasConcept C185592680 @default.
- W2380431390 hasConcept C22885893 @default.
- W2380431390 hasConcept C2777952318 @default.
- W2380431390 hasConcept C2778816929 @default.
- W2380431390 hasConcept C2779059548 @default.
- W2380431390 hasConcept C2779134260 @default.
- W2380431390 hasConcept C2779483572 @default.
- W2380431390 hasConcept C2779570518 @default.
- W2380431390 hasConcept C2781161787 @default.
- W2380431390 hasConcept C44752575 @default.
- W2380431390 hasConcept C55493867 @default.
- W2380431390 hasConcept C71924100 @default.
- W2380431390 hasConcept C80161118 @default.
- W2380431390 hasConceptScore W2380431390C126322002 @default.
- W2380431390 hasConceptScore W2380431390C134018914 @default.
- W2380431390 hasConceptScore W2380431390C148762608 @default.
- W2380431390 hasConceptScore W2380431390C15744967 @default.
- W2380431390 hasConceptScore W2380431390C169760540 @default.
- W2380431390 hasConceptScore W2380431390C170493617 @default.
- W2380431390 hasConceptScore W2380431390C181199279 @default.
- W2380431390 hasConceptScore W2380431390C185592680 @default.
- W2380431390 hasConceptScore W2380431390C22885893 @default.
- W2380431390 hasConceptScore W2380431390C2777952318 @default.
- W2380431390 hasConceptScore W2380431390C2778816929 @default.
- W2380431390 hasConceptScore W2380431390C2779059548 @default.
- W2380431390 hasConceptScore W2380431390C2779134260 @default.
- W2380431390 hasConceptScore W2380431390C2779483572 @default.
- W2380431390 hasConceptScore W2380431390C2779570518 @default.
- W2380431390 hasConceptScore W2380431390C2781161787 @default.
- W2380431390 hasConceptScore W2380431390C44752575 @default.
- W2380431390 hasConceptScore W2380431390C55493867 @default.
- W2380431390 hasConceptScore W2380431390C71924100 @default.
- W2380431390 hasConceptScore W2380431390C80161118 @default.
- W2380431390 hasLocation W23804313901 @default.
- W2380431390 hasOpenAccess W2380431390 @default.
- W2380431390 hasPrimaryLocation W23804313901 @default.
- W2380431390 hasRelatedWork W2084061481 @default.
- W2380431390 hasRelatedWork W2110330793 @default.
- W2380431390 hasRelatedWork W2319982678 @default.
- W2380431390 hasRelatedWork W2349089140 @default.
- W2380431390 hasRelatedWork W2355063108 @default.
- W2380431390 hasRelatedWork W2355653291 @default.
- W2380431390 hasRelatedWork W2358410271 @default.
- W2380431390 hasRelatedWork W2361730839 @default.
- W2380431390 hasRelatedWork W2368079718 @default.
- W2380431390 hasRelatedWork W2369685874 @default.
- W2380431390 hasRelatedWork W2372895544 @default.
- W2380431390 hasRelatedWork W2374272220 @default.
- W2380431390 hasRelatedWork W2377080959 @default.
- W2380431390 hasRelatedWork W2379971951 @default.
- W2380431390 hasRelatedWork W2427547232 @default.
- W2380431390 hasRelatedWork W2562627876 @default.
- W2380431390 hasRelatedWork W2765626597 @default.
- W2380431390 hasRelatedWork W2908382463 @default.
- W2380431390 hasRelatedWork W3029544526 @default.
- W2380431390 hasRelatedWork W3042748769 @default.
- W2380431390 isParatext "false" @default.
- W2380431390 isRetracted "false" @default.
- W2380431390 magId "2380431390" @default.
- W2380431390 workType "article" @default.