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- W2380447712 abstract "AIM:To observe the activation of signal transducer and activator of transcription 1(STAT-1) and the expression of regulated on activation,normal T-cell expression and secreted(RANTES) in rat model of chronic nonbacteria prostatitis induced by estrogen(E2).METHODS:Eighty aged male rats were randomized into control group,castration group,E2+castration group and E2+AG490+castration group.The pathological changes of the prostate tissues in the rats were observed under microscope with HE staining.The protein expression of STAT-1 and p-STAT-1 in rat prostate tissues was examined by Western blotting.The expression of RANTES at mRNA and protein levels was detected by RT-PCR and immunohistochemistry.The correlation between p-STAT-1 and RANTES was also analyzed.RESULTS:Obvious inflammatory reactions were found in E2+castration group.STAT-1 protein was in activated state and the expression of RANTES at mRNA and protein levels increased in E2+castration group as compared with control group and castration group.On the contrary,the phosphorylation of STAT-1 protein was markedly suppressed,and the mRNA and protein expression of RANTES in E2+AG490+castration group was notably lower than those in E2+castration group.There was a positive correlation between the activation of STAT-1 protein and the mRNA level of RANTES(r=0.735,P0.05),and a positive correlation of RANTES expression between mRNA and protein levels was also observed(r=0.694,P0.05).CONCLUSION:The promotive effects of transcription factor STAT-1 on RANTES expression and inflammatory response may be involved in the molecular mechanism of estrogen-induced chronic nonbacterial prostatitis." @default.
- W2380447712 created "2016-06-24" @default.
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- W2380447712 date "2013-01-01" @default.
- W2380447712 modified "2023-09-22" @default.
- W2380447712 title "Estrogen regulates transcription factor STAT-1 to promote RANTES expression and inflammatory response in rat prostate" @default.
- W2380447712 hasPublicationYear "2013" @default.
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