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- W2380448134 abstract "Objective To investigate the effects of MRI in guiding and monitioning the targeted blood-brain barrier(BBB) disruption by focused ultrasound and drug delivery to rabbit brain.Methods Twenty-five New Zealand white rabbits were e- qually divided into 5 groups.All rabbits were sonieated in the left brain hemisphere by MRI-guided focused ultrasound,the targeted locations were included in the sonicated group,the nontargeted contralateral counterparts were included in the con- trol group.Omniscan and methotrexate(MTX)were injected into the ear vein at 0,2,4,8,24 h after the sonication re- spectively.Then T1W contrast-enhanced MRI was performed,the percent enhancement of signal intensity in the sonieated area was compared with that achieved in the control area,thus the BBB disruption in the targeted area was judged,it was al- so examined by the staining of Evans blue(EB)in the targeted brain parenchyma.Determinations of MTX in all the samples were performed by high-performance liquid chromatography,the Pearson analysis was used to analyze the correlation be- tween the MTX concentration and the percent enhancement of signal intensity in the targeted area.Results BBB disruption was seen as enhancing spots at the targeted focal locations in the T1WI contrast-enhanced scans.It was at the same location which planned by T2WI before the sonication,and also in complete consistence with the result of EB staining in the targeted brain parenchyma.The correlation between MTX concentration and MRI signal intensity change in the targeted area was ob- vious,their correlative coefficient was 0.96(P0.01).Conclusion MRI can guide and monitor focused ultrasound disrup- ting BBB and delivering drug to targeted brain locations.It may provide an ideal tool in personalized treatment of centra] nervous system diseases." @default.
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- W2380448134 date "2009-01-01" @default.
- W2380448134 modified "2023-09-25" @default.
- W2380448134 title "MRI-guided targeted blood-brain barrier disruption and drug delivery to rabbit brain with focused ultrasound" @default.
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