Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380450093> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2380450093 abstract "Objective: To explore the effect of method of reducing fire and resolving stasis to dredge the orifice(RRDO) on iNOSmRNA and MMP-2mRNA expressions of cochlea ischemia reperfusion injury.Method:60 healthy guinea pigs were randomly divided into 5 groups.Animal model and grouping: photochemical induction method was used in modeling,then the guinea pig models were divided into five groups,namely normal group,model group,qi-promoting group,blood-activating group and RRDO group,with 12 guinea pigs in each group.Experimental method: 2 mL of 0.9% normal saline twice a day for the normal group;2 mL of 0.9% normal saline twice a day for the model group 12 h after the operation;and different treatments for the rest three groups.The specimens of the guinea pigs were sampled after quick decapitation on the 2nd day after administration of anesthesia.for RRDO group: 12 h after the operation,administration of the RRDO decoction,2 mL,twice a day(amounting to 1 g/d for the raw medicine);for the blood-activating group: administration of the ingredients activating blood to resolve stasis in the RRDO decoction,2 mL,twice a day(amounting to 2 g/d for the raw medicine);for the qi-promoting group: administration of the ingredients the qi-promoting simply in the RRDO decoction,2 mL,twice a day(amounting to 4 g/d for the raw medicine).The course of treatment consisted of 10 days.Expressions of cochlear iNOSmRNA and MMP-2mRNA were determined by using Real-Time PCR after 10 days.Results: In the normal group and all the 3 treatment groups,the expressions of iNOSmRNA were significantly lower than that in the model group(P0.05).The expression of iNOSmRNA in the RRDO group was similar with that in the blood-activating group(P0.05).The expression of iNOSmRNA in the model group was about 1.3 times what it was in the qi-promoting group,about 4.7 times what it was in the blood-activating group,and about 4.6 times what it was in the RRDO group.In every treatment group,the expression of MMP-2mRNA was significantly lower than that in the model group(P0.05).In the model group,the expression of MMP-2mRNA was 1.5 times what it was in the qi-promoting group;2.4 times what it was in the blood-activating group;and 7.3 times what it was in the RRDO group.Conclusion: 1.Both RRDO therapy and activating blood to resolve stasis therapy can inhibit the expression of iNOS to protect cochlear tissue ischemia,and they are better than qi-promoting therapy.2.Therapies of RRDO,activating blood to resolve stasis,and promoting qi all can inhibit the expression of MMP-2,and the function of RRDO is the most powerful." @default.
- W2380450093 created "2016-06-24" @default.
- W2380450093 creator A5081086943 @default.
- W2380450093 date "2013-01-01" @default.
- W2380450093 modified "2023-09-26" @default.
- W2380450093 title "Experimental Research on Method of Reducing Fire and Resolving Stasis to Dredge Orifice and Improve Cochlea Ischemia Reperfusion Injury" @default.
- W2380450093 hasPublicationYear "2013" @default.
- W2380450093 type Work @default.
- W2380450093 sameAs 2380450093 @default.
- W2380450093 citedByCount "0" @default.
- W2380450093 crossrefType "journal-article" @default.
- W2380450093 hasAuthorship W2380450093A5081086943 @default.
- W2380450093 hasConcept C126322002 @default.
- W2380450093 hasConcept C142724271 @default.
- W2380450093 hasConcept C188947578 @default.
- W2380450093 hasConcept C190409667 @default.
- W2380450093 hasConcept C204787440 @default.
- W2380450093 hasConcept C2776379591 @default.
- W2380450093 hasConcept C2777397205 @default.
- W2380450093 hasConcept C2778815084 @default.
- W2380450093 hasConcept C2780114680 @default.
- W2380450093 hasConcept C2992013202 @default.
- W2380450093 hasConcept C42219234 @default.
- W2380450093 hasConcept C541997718 @default.
- W2380450093 hasConcept C556039675 @default.
- W2380450093 hasConcept C71924100 @default.
- W2380450093 hasConceptScore W2380450093C126322002 @default.
- W2380450093 hasConceptScore W2380450093C142724271 @default.
- W2380450093 hasConceptScore W2380450093C188947578 @default.
- W2380450093 hasConceptScore W2380450093C190409667 @default.
- W2380450093 hasConceptScore W2380450093C204787440 @default.
- W2380450093 hasConceptScore W2380450093C2776379591 @default.
- W2380450093 hasConceptScore W2380450093C2777397205 @default.
- W2380450093 hasConceptScore W2380450093C2778815084 @default.
- W2380450093 hasConceptScore W2380450093C2780114680 @default.
- W2380450093 hasConceptScore W2380450093C2992013202 @default.
- W2380450093 hasConceptScore W2380450093C42219234 @default.
- W2380450093 hasConceptScore W2380450093C541997718 @default.
- W2380450093 hasConceptScore W2380450093C556039675 @default.
- W2380450093 hasConceptScore W2380450093C71924100 @default.
- W2380450093 hasLocation W23804500931 @default.
- W2380450093 hasOpenAccess W2380450093 @default.
- W2380450093 hasPrimaryLocation W23804500931 @default.
- W2380450093 hasRelatedWork W1964300242 @default.
- W2380450093 hasRelatedWork W2225200993 @default.
- W2380450093 hasRelatedWork W2315912140 @default.
- W2380450093 hasRelatedWork W2337625597 @default.
- W2380450093 hasRelatedWork W2351538095 @default.
- W2380450093 hasRelatedWork W2373412242 @default.
- W2380450093 hasRelatedWork W2387941647 @default.
- W2380450093 hasRelatedWork W2400920723 @default.
- W2380450093 hasRelatedWork W2418334348 @default.
- W2380450093 hasRelatedWork W3028646784 @default.
- W2380450093 hasRelatedWork W3028742054 @default.
- W2380450093 hasRelatedWork W3029614867 @default.
- W2380450093 hasRelatedWork W3030122420 @default.
- W2380450093 hasRelatedWork W3030349171 @default.
- W2380450093 hasRelatedWork W3030914209 @default.
- W2380450093 hasRelatedWork W3030998889 @default.
- W2380450093 hasRelatedWork W3031663215 @default.
- W2380450093 hasRelatedWork W3031751670 @default.
- W2380450093 hasRelatedWork W3032448592 @default.
- W2380450093 hasRelatedWork W3030565165 @default.
- W2380450093 isParatext "false" @default.
- W2380450093 isRetracted "false" @default.
- W2380450093 magId "2380450093" @default.
- W2380450093 workType "article" @default.