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- W2380451224 abstract "Objective: To observe the effect of Zhilong Huoxue Tongyu Capsule( ZHTC) on nerve cell apoptosis,the protein expression of HIF-1α and PAR-1 in intracerebral hemorrhage rats. According to those we could further elucidate ZHTC's possible effects on brain protection. Methods: The rats were randomly divided into five groups: sham-operation group,model group,low-dose ZHTC group,moderate-dose ZHTC group and high-dose ZHTC group. Autologous blood injection method was used to produce cerebral hemorrhage model. TUNEL method was made for determining the apoptotic cells expression and immunohistochemical method for determining the expression of HIF-1α and PAR-1 protein. Results: Compared with the model group, the apoptotic cell and the expression of PAR-1 protein of each ZHTC group significantly decreased( P 0. 01),the expression of HIF-1 protein significantly raised( P 0. 01); Compared with the low-dose ZHTC group,the apoptotic cell and the expression of PAR-1 protein of moderate-dose ZHTC group and high-dose ZHTC group significantly decreased( P 0. 01),the expression of HIF-1 protein significantly raised( P 0. 01). Conclusion: ZHTC can obviously promote HIF-1 expression,inhibit PAR-1 expression and reduce the apoptosis. The protective effect of ZHTC for ICH rats has a certain dose-effect relationship." @default.
- W2380451224 created "2016-06-24" @default.
- W2380451224 creator A5032080056 @default.
- W2380451224 date "2013-01-01" @default.
- W2380451224 modified "2023-09-23" @default.
- W2380451224 title "Experimental Study on the Effect of Zhilong Huoxue Tongyu Capsule on Nerve Cell Apoptosis and the Protein Ex- pression of HIF-1α and PAR-1 in Intracerebral Hemorrhage Rats" @default.
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